GuidelineHeart rhythm2023
2023 HRS/APHRS/LAHRS guideline on cardiac physiologic pacing for the avoidance and mitigation of heart failure.
3 registry-linked trialsOpen access · greenAbstract readPractice Guideline
In one paragraph
Guideline in Heart rhythm, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 248 papers, 12 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
248citing papers in PubMed, 12 pooled it
95.7field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Conduction System Pacing Versus Biventricular Pacing for Heart Failure Patients With Right Ventricular Pacing Upgraded to Cardiac Resynchronization Therapy: a Prospective Multicenter Non-inferiority Randomized Controlled Study
NCT07664189 naenrolling by invitationnot on this mapstarted 2026, after this paper: background citation
Left Bundle Branch Pacing + Coronary Sinus Pacing Versus Left Bundle Branch Pacing Alone for Cardiac Resynchronization Therapy in Patients Eligible for CRT-P A Randomized Crossover Pilot Clinical Trial
Right Ventricular Septal Biopsy to Detect Cardiac Amyloidosis in At-Risk Population: A Prospective Study
Who cites it
248 citing papers in PubMed, 12 syntheses or guidelines pooled it, 438 citations in OpenAlex.
- Pacing-Induced Cardiomyopathy in Leadless and Transvenous Pacemakers: A Meta-Analysis and Meta-Regression.Pacing and clinical electrophysiology : PACE · 2026Pooled it
- Heart failure with reduced ejection fraction: a systematic review of clinical practice guidelines and recommendations.European heart journal. Quality of care & clinical outcomes · 2026Pooled it
- Conduction system pacing vs. biventricular pacing for cardiac resynchronization therapy in heart failure: a systematic review and meta-analysis considering randomized controlled trials and observational studies.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2026Pooled it
- Pooled it
- Conduction System Pacing Versus Biventricular Cardiac Resynchronization Pacing: Meta-Analysis on Outcomes in Patients with Non-Left Bundle Branch Block.Medicina (Kaunas, Lithuania) · 2025Pooled it
- Systematic Review and Meta-Analysis of Acute Mortality and Complication Rates Following Leadless Pacemaker Placement Using National-Level Data.Medicina (Kaunas, Lithuania) · 2025Pooled it
- The Risk of New-Onset Atrial Fibrillation in Patients With Conduction System Pacing Versus Right Ventricular Pacing: A Meta-Analysis.Reviews in cardiovascular medicine · 2025Pooled it
- ACC/AHA/ASE/HFSA/HRS/SCAI/SCCT/SCMR 2025 Appropriate Use Criteria for Implantable Cardioverter-Defibrillators, Cardiac Resynchronization Therapy, and Pacing.Journal of the American College of Cardiology · 2025Guideline
- Left bundle branch area pacing vs. biventricular pacing significantly improves clinical outcomes and cardiac remodeling in cardiac resynchronization therapy: a systematic review and meta-analysis.Frontiers in cardiovascular medicine · 2025Pooled it
- Systematic review and meta-analysis on the impact on outcomes of device algorithms for minimizing right ventricular pacing.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2024Pooled it
- Evolution and prognosis of tricuspid and mitral regurgitation following cardiac implantable electronic devices: a systematic review and meta-analysis.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2024Pooled it
- Relationship between sex, body size, and cardiac resynchronization therapy benefit: A patient-level meta-analysis of randomized controlled trials.Heart rhythm · 2024Pooled it
- Cardiac resynchronization therapy with or without atrioventricular node ablation in atrial fibrillation: the CAAN-AF trial.European heart journal · 2026Trial
- Long-Term Outcomes of Left Bundle-Branch Pacing vs Biventricular Pacing in Heart Failure: The HeartSync-LBBP Randomized Clinical Trial.JAMA cardiology · 2026Trial
- Clinical Outcomes With Personalized Accelerated Physiologic Pacing in Heart Failure With Preserved Ejection Fraction: Follow-up of the myPACE Trial.JAMA cardiology · 2025Trial
- Multipoint pacing is associated with reduction of heart failure hospitalizations or death in patients who do not respond to cardiac resynchronization therapy: results of the MORE-CRT MPP randomized trial.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2025Trial
- Multipoint pacing is associated with improved prognosis and cardiac resynchronization therapy response: MORE-CRT MPP randomized study secondary analyses.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2024Trial
- Echocardiographic screening for heart failure and optimization of the care pathway for individuals with pacemakers: a randomized controlled trial.Nature medicine · 2024Trial
- Longitudinal comparison of dyssynchrony correction and 'strain' improvement by conduction system pacing: LEVEL-AT trial secondary findings.European heart journal. Cardiovascular Imaging · 2024Trial
- Closed loop stimulation reduces the incidence of atrial high-rate episodes compared with conventional rate-adaptive pacing in patients with sinus node dysfunctions.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2024Trial
188 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
60 authors at 20 institutions in 14 countries.
Mina K ChungCleveland Clinic, Cleveland, Ohio.
Kristen K PattonUniversity of Washington, Seattle, Washington.
Chu-Pak LauUniversity of Hong Kong, Hong Kong, China.
Alexander R J Dal FornoHospital SOS Cárdio, Florianópolis, Brazil.
Sana M Al-KhatibDuke University Medical Center, Durham, North Carolina.
Vanita AroraIndraprastha Apollo Hospital, New Delhi, India.
Ulrika Maria Birgersdotter-GreenUniversity of California San Diego Health, La Jolla, California.
Yong-Mei ChaMayo Clinic, Rochester, Minnesota.
Eugene H ChungUniversity of Michigan Medical School, Ann Arbor, Michigan.
Edmond M CroninTemple University, Philadelphia, Pennsylvania.
Anne B CurtisUniversity at Buffalo, Buffalo, New York.
Iwona CygankiewiczMedical University of Łódź, Łódź, Poland.
Gopi DandamudiVirginia Mason Franciscan Health, Tacoma, Washington.
Anne M DubinStanford University, Pediatric Cardiology, Palo Alto, California.
Douglas P EnschCleveland Clinic, Cleveland, Ohio.
Taya V GlotzerHackensack Meridian School of Medicine, Hackensack, New Jersey.
Michael R GoldMedical University of South Carolina, Charleston, South Carolina.
Zachary D GoldbergerUniversity of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.
Rakesh GopinathannairKansas City Heart Rhythm Institute, Overland Park, Kansas.
Eiran Z GorodeskiUniversity Hospitals and Case Western Reserve University School of Medicine, Cleveland, Ohio.
Alejandra GutierrezUniversity of Minnesota, Minneapolis, Minnesota.
Juan C GuzmanMcMaster University, Hamilton, Ontario, Canada.
Weijian HuangFirst Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Peter B ImreyCleveland Clinic, Cleveland, Ohio; Case Western Reserve University, Cleveland, Ohio.
Julia H IndikUniversity of Arizona, Sarver Heart Center, Tucson, Arizona.
Saima KarimMetroHealth Medical Center, Case Western Reserve University, Cleveland, Ohio.
Peter P KarpawichThe Children's Hospital of Michigan, Central Michigan University, Detroit, Michigan.
Yaariv KhaykinSouthlake Regional Health Center, Newmarket, Ontario, Canada.
Erich L KiehlSentara, Norfolk, Virginia.
Jordana KronVirginia Commonwealth University, Richmond, Virginia.
Valentina KutyifaUniversity of Rochester Medical Center, Rochester, New York.
Mark S LinkUniversity of Texas Southwestern Medical Center, Dallas, Texas.
Joseph E MarineJohns Hopkins University School of Medicine, Baltimore, Maryland.
Wilfried MullensZiekenhuis Oost-Limburg Genk, Belgium and Hasselt University, Hasselt, Belgium.
Seung-Jung ParkSungkyunkwan University School of Medicine, Samsung Medical Center, Seoul, Republic of Korea.
Ratika ParkashQEII Health Sciences Center, Halifax, Nova Scotia, Canada.
Manuel F PateteClinica Corazones Unidos, Santo Domingo, Dominican Republic.
Rajeev Kumar PathakAustralian National University, Canberra Hospital, Garran, Australian Capital Territory, Australia.
Carlos A PeronaSantojanni Hospital, Buenos Aires, Argentina.
John RickardCleveland Clinic, Cleveland, Ohio.
Mark H SchoenfeldYale University School of Medicine, New Haven, Connecticut.
Swee-Chong SeowNational University Hospital Singapore, Singapore.
Win-Kuang ShenMayo Clinic, Phoenix, Arizona.
Morio ShodaTokyo Women's Medical University, Tokyo, Japan.
Jagmeet P SinghMassachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
David J SlotwinerWeill Cornell Medicine Population Health Sciences, New York, New York.
Arun Raghav M SridharUniversity of Washington, Seattle, Washington.
Uma N SrivatsaUniversity of California Davis, Sacramento, California.
Eric C SteckerOregon Health & Science University, Portland, Oregon.
Tanyanan TanawuttiwatIndiana University, Indianapolis, Indiana.
W H Wilson TangCleveland Clinic, Cleveland, Ohio.
Carlos Andres TapiasFundación Cardioinfantil Instituto de Cardiologia, Bogotá, Colombia.
Cynthia M TracyGeorge Washington University, Washington, District of Columbia.
Gaurav A UpadhyayUniversity of Chicago Medicine, Chicago, Illinois.
Niraj VarmaCleveland Clinic, Cleveland, Ohio.
Kevin VernooyCardiovascular Research Institute Maastricht, Maastricht University Medical Center, Maastricht, The Netherlands.
Pugazhendhi VijayaramanGeisinger Health System, Wilkes-Barre, Pennsylvania.
Sarah Ann WorsnickGeisinger Health System, Wilkes-Barre, Pennsylvania.
Wojciech ZarebaUniversity of Rochester Medical Center, Rochester, New York.
Emily P ZeitlerDartmouth Hitchcock Medical Center, Lebanon, New Hampshire.
Cleveland Clinic · USGeisinger Health System · USUniversity of Rochester Medical Center · USUniversity of Washington · USAustralian National University · AUCase Western Reserve University · USChildren's Hospital of Michigan · USDartmouth–Hitchcock Medical Center · USDuke Medical Center · USFranciscan Health · USGeorge Washington University · USHackensack Meridian Health · USHasselt University · BEHeart Rhythm Society · USHospital Donación Francisco Santojanni · ARIndiana University – Purdue University Indianapolis · USIndraprastha Apollo Hospitals · INInstitute of Cardiology · COJohns Hopkins Medicine · USMaastricht University · NL
Funding
Project 3 Genes to Omics-Informed Drugs: Drug Repositioning and Testing to Prevent AF ProgressionsP01HL158502 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI Mina Kay Chung · 2022 to 2026
$16.9MRADIOMIC APPROACHES TO IMPROVE TARGETING FOR ATRIAL FIBRILLATION CATHETER ABLATIONR01HL158071 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI BARNARD, JOHN, CHUNG, MINA KAY · 2021 to 2024
$2.9MBLRD VA IK6 BX006185NHLBI NIH HHS P01 HL158502NHLBI NIH HHS R01 HL158071
Abstract
Cardiac physiologic pacing (CPP), encompassing cardiac resynchronization therapy (CRT) and conduction system pacing (CSP), has emerged as a pacing therapy strategy that may mitigate or prevent the development of heart failure (HF) in patients with ventricular dyssynchrony or pacing-induced cardiomyopathy. This clinical practice guideline is intended to provide guidance on indications for CRT for HF therapy and CPP in patients with pacemaker indications or HF, patient selection, pre-procedure evaluation and preparation, implant procedure management, follow-up evaluation and optimization of CPP response, and use in pediatric populations. Gaps in knowledge, pointing to new directions for future research, are also identified.
Indexed as
Cardiac Resynchronization TherapyHeart FailureBundle of HisCardiac Conduction System DiseaseChildElectrocardiographyHumansTreatment OutcomeCardiac resynchronization therapyConduction system pacingGuidelineHis bundle pacingLeft bundle branch area pacing
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.