ArticleZhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences2023
Therapeutic effect of menstrual blood stem cells in rats with thin endometrium.
Article in Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 6 citations in OpenAlex.
- Role and mechanism of mesenchymal stem cells in endometrial receptivity remodeling.Frontiers in cell and developmental biology · 2026Review
- Molecular pathways and immune microenvironment regulation in stem cell therapy for thin endometrium: a comprehensive narrative review.Frontiers in immunology · 2026Review
- Therapeutic potential of super activated platelet lysate (sPL) and umbilical cord mesenchymal stem cells (UCMSCs) in enhancing endometrial regeneration in rats with thin endometrium.Scientific reports · 2025Article
- Effects of platelet-rich fibrin on human endometrial stromal cells behavior in comparison to platelet-rich plasma.Frontiers in cell and developmental biology · 2024Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
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Abstract
objectivesTo explore the therapeutic effect of transplantation of menstrual blood stem cells (MenSCs) in rats with thin endometrium.
methodsThirty SPF grade female SD rats aged 8-10 weeks were randomly divided into model control group and MenSC group, with 15 rats in each group. The thin endometrium injury model was prepared by chemical method in one side of the uterus of both groups. On the 7th day of modeling, normal saline or the third generation of MenSCs were injected into the model uterus at multiple points, and the other side of the uterus was used as an internal control without treatment. HE staining was used to observe the histological structure of endometrium; immunohistochemical staining was used to observe the expression of cyto-keratin (CK) 18 and vimentin in endometrial tissue; 5-ethynyl-2'-deoxyuridine (EdU) cell proliferation assay was used to evaluate the cell proliferation in endometrial tissue; immunofluorescence staining was used to detect the expression of vascular endothelial marker CD34 and vascular endothelial growth factor (VEGF) in endometrial tissue; the expression of leukemia inhibitory factor (LIF), integrin β3 (ITGβ3) and homeobox A10 (HOXA10) in endometrial tissue was determined by realtime RT-PCR. After treatments, the female and male rats were caged in a ratio of 2∶1 to observe the effect of MenSC on the reproductive function of thin endometrium model rats.
resultsCompared with the surgical control group, the endometrium in the model control group was thinner, and the numbers of glands and blood vessels were less (all
conclusionsMenSC transplantation can promote the proliferation of endometrial cells, upregulate vimentin, CK18, CD34 and VEGF levels, and promote the recovery of endometrial morphology and function, thus improving the endometrial receptivity and fertility of the rats with thin endometrium.
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