ReviewCritical reviews in food science and nutrition2024
Total (poly)phenol analysis by the Folin-Ciocalteu assay as an anti-inflammatory biomarker in biological samples.
Review in Critical reviews in food science and nutrition, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 77 citations in OpenAlex.
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- The Influence of Water Extraction Methods on the Isolation of Polyphenols and Tannins from Various Ericaceae and Rosaceae Species.Plants (Basel, Switzerland) · 2026Article
- The Significant Antioxidant Effect Exerted by Pomegranate (Antioxidants (Basel, Switzerland) · 2026Article
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- Integrated Analysis of Commercial Coffee Samples from Saudi Arabia: Evaluation of Elemental Composition, Phytochemicals, Antioxidant Activity, and Statistical Profiling.Biological trace element research · 2026Article
- Regional variability in phytochemical profiles and bioactivities of macerate and decoction extracts from three medicinal plants of Burkina Faso.Frontiers in plant science · 2026Article
- Dynamic Fibrous Hydrogels for Stem Cell Homing and In Situ Bone Regeneration.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Clinical Implementation of Sustainable Functional Foods and Nutraceuticals in Metabolic Health: A Feasibility Study.Nutrients · 2025Article
- Optimization of Ultrasound-Assisted Methanolic Extraction ofFood science & nutrition · 2025Article
- Phytochemical Constituent of Devil Weed (Molecules (Basel, Switzerland) · 2025Article
- Antioxidant Properties of Food-Derived Lactic Acid Bacteria: A Review.Microbial biotechnology · 2025Review
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- Protective Effects of Pectin From Honey-Processed Hawthorn on Acute Myocardial Ischemia.Food science & nutrition · 2025Article
- Enhancement of antiphotoaging properties of Cannabis sativa stem water extracts by fermentation with Lacticaseibacillus casei.PloS one · 2025Article
- Small Steps to the Big Picture for Health-Promoting Applications Through the Use of Chickweed (Food science & nutrition · 2024Article
- Structure-dependent detection of polyphenols using crown ether-immobilized gold nanoparticles.RSC advances · 2024Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The Folin-Ciocalteu method is a well-established and widely used assay for measuring total (poly)phenol content in food/plant products. In recent years, there has been growing interest in applying this method to human samples due to its simplicity and efficacy. However, biological matrices such as blood and urine contain several interference substances that must be eliminated beforehand. This mini-review summarizes the current state of knowledge regarding the use of the Folin-Ciocalteu assay to measure total phenolic content in human urine and blood samples, as well as the preceding cleaning methods to remove interferences. Higher total (poly)phenol levels measured by the Folin-Ciocalteu method have been associated with a decrease in mortality and several risk variables. We focus on the application of this sustainable assay as a biomarker of poly(phenol) intake and its potential use as an anti-inflammatory biomarker in clinical laboratories. The Folin-Ciocalteu method, with a clean-up extraction step, is a reliable tool for determining total (poly)phenol consumption. Here, we also recommend using the Folin-Ciocalteu assay as means to measure anti-inflammatory activity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.