ArticleJournal of the American Geriatrics Society2023
Increase in skeletal muscular adiposity and cognitive decline in a biracial cohort of older men and women.
Article in Journal of the American Geriatrics Society, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 16 citations in OpenAlex.
- Exploring the link between body physiology and cognition: the role of the brain and aging.npj aging · 2026Article
- Abdominal adiposity and Alzheimer's disease imaging markers across sex and race at midlife.Journal of Alzheimer's disease : JAD · 2026Article
- The association of thigh myosteatosis with lower cognitive function in older cancer survivors.GeroScience · 2026Article
- Skeletal muscle adiposity and cognitive decline in a biracial cohort: Insights from coronary artery risk development in young adults (CARDIA) study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Metabolomic insight into the link of intermuscular fat with cognitive performance: the Health ABC Study.GeroScience · 2025Article
- Abdominal myosteatosis is associated with lower processing speed in a multiethnic cohort of older adults.Archives of gerontology and geriatrics · 2025Article
- Plasma proteomic analysis of intermuscular fat links muscle integrity with processing speed in older adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Article
- To Be Frail or Not to Be Frail: This Is the Question-A Critical Narrative Review of Frailty.Journal of clinical medicine · 2024Review
- Linking sarcopenia, brain structure and cognitive performance: a large-scale UK Biobank study.Brain communications · 2024Article
- Operational Modal Analysis of Near-Infrared Spectroscopy Measure of 2-Month Exercise Intervention Effects in Sedentary Older Adults with Diabetes and Cognitive Impairment.Brain sciences · 2023Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundObesity and loss of muscle mass are emerging as risk factors for dementia, but the role of adiposity infiltrating skeletal muscles is less clear. Skeletal muscle adiposity increases with older age and especially among Black women, a segment of the US population who is also at higher risk for dementia.
methodsIn 1634 adults (69-79 years, 48% women, 35% Black), we obtained thigh intermuscular adipose tissue (IMAT) via computerized tomography at Years 1 and 6, and mini-mental state exam (3MS) at Years 1, 3, 5, 8 and 10. Linear mixed effects models tested the hypothesis that increased IMAT (Year 1-6) would be associated with 3MS decline (Year 5-10). Models were adjusted for traditional dementia risk factors at Year 1 (3MS, education, APOe4 allele, diabetes, hypertension, and physical activity), with interactions between IMAT change by race or sex. To assess the influence of other muscle and adiposity characteristics, models accounted for change in muscle strength, muscle area, body weight, abdominal subcutaneous and visceral adiposity, and total body fat mass (all measured in Years 1 and 6). Models were also adjusted for cytokines related to adiposity: leptin, adiponectin, and interleukin-6.
resultsThigh IMAT increased by 4.85 cm
conclusionsClinicians should be aware that regional adiposity accumulating in the skeletal muscle may be an important, novel risk factor for cognitive decline in Black and White participants independent of changes to muscle strength, body composition and traditional dementia risk factors.
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