Evidence map›Paper›PMID 37282638›Full record

ArticleCurrent drug discovery technologies2024

Nanoencapsulation of Ruthenium Complex Ru(ThySMet): A Strategy to Improve Selective Cytotoxicity against Breast Tumor Cells in 2D and 3D Culture Models.

Amanda Blanque Becceneri, Angelina Maria Fuzer, Ana Carolina Lopes, Patrícia Bento da Silva, Ana Maria Plutin, Alzir Azevedo Batista, Marlus Chorilli, Márcia Regina Cominetti

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Article in Current drug discovery technologies, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Amanda Blanque BecceneriDepartment of Gerontology, Federal University of São Carlos. Rod. Washington Luís, Km 235, São Carlos, São Paulo, 13565-905, Brazil.
Angelina Maria FuzerDepartment of Gerontology, Federal University of São Carlos. Rod. Washington Luís, Km 235, São Carlos, São Paulo, 13565-905, Brazil.
Ana Carolina LopesSchool of Pharmaceutical Sciences, São Paulo State University, Rodovia Araraquara-Jau, km. 1, Araraquara, São Paulo, 14800-903, Brazil.
Patrícia Bento da SilvaSchool of Pharmaceutical Sciences, São Paulo State University, Rodovia Araraquara-Jau, km. 1, Araraquara, São Paulo, 14800-903, Brazil.
Ana Maria PlutinFacultad de Química, Universidad de la Habana. Zapata s/n entre G y Carlitos Aguirre, Habana, 10400, Cuba.
Alzir Azevedo BatistaDepartment of Chemistry, Federal University of São Carlos. Rod. Washington Luís, Km 235, São Carlos, São Paulo, 13565-905, Brazil.
Marlus ChorilliSchool of Pharmaceutical Sciences, São Paulo State University, Rodovia Araraquara-Jau, km. 1, Araraquara, São Paulo, 14800-903, Brazil.
Márcia Regina CominettiDepartment of Gerontology, Federal University of São Carlos. Rod. Washington Luís, Km 235, São Carlos, São Paulo, 13565-905, Brazil.
Universidade Estadual Paulista (Unesp) · BRUniversidade Federal de São Carlos · BRUniversidade de São Paulo · BRUniversity of Havana · CU

Funding

(FAPESP ) Fundação de Amparo à Pesquisa do Estado de São Paulo, Brazil Grants #2014/25121-8; #2017/01287-2; #2020/03367-6
6 · The paper itself

Abstract

backgroundRuthenium complexes have shown promise in treating many cancers, including breast cancer. Previous studies of our group have demonstrated the potential of the trans- [Ru(PPh3)2(N,N-dimethylN'-thiophenylthioureato-k2O,S)(bipy)]PF6 complex, the Ru(ThySMet), in the treatment of breast tumor cancers, both in 2D and 3D culture systems. Additionally, this complex presented low toxicity when tested

aimsImprove the Ru(ThySMet) activity by incorporating the complex into a microemulsion (ME) and testing its

methodsThe ME-incorporated Ru(ThySMet) complex, Ru(ThySMet)

resultsAn increased selective cytotoxicity of the Ru(ThySMet)

conclusionThese results demonstrate that the Ru(ThySMet)

Indexed as

Antineoplastic AgentsBreast NeoplasmsAnimalsCell Culture TechniquesCell Culture Techniques, Three DimensionalCell Line, TumorCell SurvivalCoordination ComplexesDrug CompoundingEmulsionsFemaleHumansMiceRutheniumAntineoplastic AgentsCoordination ComplexesEmulsionsRuthenium2D cell culture and 3Dcell culture.in vitro studiesmicroemulsionruthenium complexesTriple-negative breast cancer

Identifiers

PMID37282638
OpenAlexW4379598618

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.