Evidence map›Paper›PMID 37282629›Full record

ReviewLab on a chip2023

Opportunities and considerations for studying liver disease with microphysiological systems on a chip.

Adiya E Otumala, Dominick J Hellen, C Alessandra Luna, Priscilla Delgado, Anjana Dissanayaka, Chidozie Ugwumadu, Oluwamayokun Oshinowo, Md Mydul Islam, Luyao Shen, Saul J Karpen and 1 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Lab on a chip, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Adiya E OtumalaThe Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology & Emory University, 1760 Haygood Dr, Suite E-160, Rm E-156, Atlanta, GA, 30332, USA. david.myers@emory.edu.
Dominick J HellenDepartment of Pediatrics, Division of Pediatric Gastroenterology, Hepatology and Nutrition, Emory University School of Medicine, Children's Healthcare of Atlanta, Atlanta, Georgia, USA.ORCID 0000-0002-2793-399X
C Alessandra LunaThe Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology & Emory University, 1760 Haygood Dr, Suite E-160, Rm E-156, Atlanta, GA, 30332, USA. david.myers@emory.edu.
Priscilla DelgadoThe Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology & Emory University, 1760 Haygood Dr, Suite E-160, Rm E-156, Atlanta, GA, 30332, USA. david.myers@emory.edu.ORCID 0000-0002-2550-5051
Anjana DissanayakaThe Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology & Emory University, 1760 Haygood Dr, Suite E-160, Rm E-156, Atlanta, GA, 30332, USA. david.myers@emory.edu.
Chidozie UgwumaduThe Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology & Emory University, 1760 Haygood Dr, Suite E-160, Rm E-156, Atlanta, GA, 30332, USA. david.myers@emory.edu.
Oluwamayokun OshinowoThe Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology & Emory University, 1760 Haygood Dr, Suite E-160, Rm E-156, Atlanta, GA, 30332, USA. david.myers@emory.edu.
Md Mydul IslamThe Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology & Emory University, 1760 Haygood Dr, Suite E-160, Rm E-156, Atlanta, GA, 30332, USA. david.myers@emory.edu.ORCID 0000-0002-0786-9150
Luyao ShenThe Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology & Emory University, 1760 Haygood Dr, Suite E-160, Rm E-156, Atlanta, GA, 30332, USA. david.myers@emory.edu.ORCID 0000-0002-3231-4878
Saul J KarpenDepartment of Pediatrics, Division of Pediatric Gastroenterology, Hepatology and Nutrition, Emory University School of Medicine, Children's Healthcare of Atlanta, Atlanta, Georgia, USA.
David R MyersThe Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology & Emory University, 1760 Haygood Dr, Suite E-160, Rm E-156, Atlanta, GA, 30332, USA. david.myers@emory.edu.ORCID 0000-0001-9659-3274

Funding

PREDOCTORAL TRAINING PROGRAM IN GENETICST32GM008490 · NIGMS · EMORY UNIVERSITY · PI BOSS, JEREMY M. · 1993 to 2022
$8.0M
Modeling genetic contributions to biliary atresiaR01DK135815 · NIDDK · VIRGINIA COMMONWEALTH UNIVERSITY · PI SAUL J. KARPEN · 2023 to 2026
$2.4M
Leveraging platelet contraction cytometry for immune thrombocytopeniaR01HL155330 · NHLBI · EMORY UNIVERSITY · PI MYERS, DAVID RICHARD · 2021 to 2025
$1.9M
Wearable Microchip for Assessing Global HemostatsisK25HL141636 · NHLBI · EMORY UNIVERSITY · PI MYERS, DAVID RICHARD · 2019 to 2023
$788k
Novel insights on immune thrombocytopenia purpura with platelet contraction cytometryF31HL160210 · NHLBI · EMORY UNIVERSITY · PI OSHINOWO, OLUWAMAYOKUN · 2021 to 2023
$155k
NHLBI NIH HHS K25 HL141636NHLBI NIH HHS R01 HL155330NIDDK NIH HHS R01 DK135815NIGMS NIH HHS T32 GM008490
6 · The paper itself

Abstract

Advances in microsystem engineering have enabled the development of highly controlled models of the liver that better recapitulate the unique

Indexed as

Lab-On-A-Chip DevicesMicrophysiological SystemsLiver

Identifiers

PMID37282629
PMCPMC13062817

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.