Evidence map›Paper›PMID 37282602›Full record

ArticleCancer biology & medicine2023

Associations between polymorphisms in leptin and leptin receptor genes and colorectal cancer survival.

Meizhi Du, Yu Wang, Jillian Vallis, Matin Shariati, Patrick S Parfrey, John R Mclaughlin, Peizhong Peter Wang, Yun Zhu

Abstract read
In one paragraph

Article in Cancer biology & medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. STAT3 Inhibition to Treat Ulcerative Colitis-Associated Colorectal Cancer.International journal of molecular sciences · 2025
    Article
  5. A systematic analysis of human hormone receptors.Science China. Life sciences · 2025
    Article
  6. Article
  7. Article
  8. Obesity-Associated Colorectal Cancer.International journal of molecular sciences · 2024
    Review
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Meizhi Du *Department of Epidemiology and Biostatistics, School of Public Health, Tianjin Medical University, Tianjin 300070, China.
Yu Wang *Department of Epidemiology and Biostatistics, School of Public Health, Tianjin Medical University, Tianjin 300070, China.
Jillian VallisDivision of Community Health and Humanities, Faculty of Medicine, Memorial University of Newfoundland, St. John's A1B 3V6, Canada.
Matin ShariatiDivision of Community Health and Humanities, Faculty of Medicine, Memorial University of Newfoundland, St. John's A1B 3V6, Canada.
Patrick S ParfreyClinical Epidemiology Unit, Faculty of Medicine, Memorial University of Newfoundland, St. John's A1B 3V6, Canada.
John R MclaughlinDalla Lana School of Public Health, University of Toronto, Toronto M5T 3M7, Canada.
Peizhong Peter WangDivision of Community Health and Humanities, Faculty of Medicine, Memorial University of Newfoundland, St. John's A1B 3V6, Canada.ORCID 0000-0002-0682-6861
Yun ZhuDepartment of Epidemiology and Biostatistics, School of Public Health, Tianjin Medical University, Tianjin 300070, China.ORCID 0000-0002-5864-0794

Funding

ONTARIO REGISTRY FOR STUDIES OF FAMILIAL COLON CANCERU01CA074783 · NCI · CANCER CARE ONTARIO · PI GALLINGER, STEVEN · 1997 to 2008
$12.5M
NCI NIH HHS U01 CA074783
6 · The paper itself

Abstract

objectiveLeptin (LEP) is an obesity-associated adipokine associated with tumor cell growth. We examined the relevance of genetic variants of

methodsA total of 532 patients newly diagnosed with CRC between 1997 and 2003 were followed up until April 2010. Data on their demographics and lifestyles were collected

resultsAt the gene level,

conclusionsPolymorphic variations in the

Indexed as

Colorectal NeoplasmsLeptinGenetic Predisposition to DiseaseHumansPolymorphism, Single NucleotideReceptors, LeptinLeptinReceptors, Leptincolorectal cancer survivalgene-environment interactionpolymorphism

Identifiers

PMID37282602
PMCPMC10291983

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.