ReviewDeutsches Arzteblatt international2023
Neoplasms of the Appendix.
Review in Deutsches Arzteblatt international, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 24 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.
- Sessile serrated lesions of the appendix: a contemporary review of the literature.BMC gastroenterology · 2026Pooled it
- Primary Signet Ring Cell Adenocarcinoma of the Appendix Masquerading as Acute Appendicitis: A Diagnostic Pitfall.Iranian journal of pathology · 2026Article
- Intraluminal Appendiceal Migration of an Intrauterine Device Without Appendicitis: A Case Report.The American journal of case reports · 2026Article
- Incidental appendiceal neoplasms in patients undergoing appendectomy for acute appendicitis: a 10-year retrospective analysis of 5001 cases.Surgical endoscopy · 2026Article
- Aggressive appendiceal malignancies mimicking primary colonic tumors: two cases with extramural invasion and atypical clinical presentation.Clinical journal of gastroenterology · 2026Article
- Low-Grade Appendiceal Mucinous Neoplasm Mimicking Pelvic Inflammatory Disease: A Case Report.Cureus · 2026Article
- Article
- Low-Grade Appendiceal Mucinous Neoplasm Presenting as an Appendiceal Mucocele: A Case Report.Cureus · 2026Article
- Prediction of distant metastasis and survival of appendiceal cancer patients: a SEER population-based study.Translational cancer research · 2026Article
- Beyond the Inflamed Appendix: Low-Grade Appendiceal Mucinous Neoplasm-Emphasis on Macroscopic Findings.Diagnostics (Basel, Switzerland) · 2026Article
- The Power of MUC2 in Mucinous Adenocarcinomas.Pathobiology : journal of immunopathology, molecular and cellular biology · 2026Review
- Low-Grade Appendiceal Mucinous Neoplasm as an Incidental Finding During Cesarean Section: A Case Report.The American journal of case reports · 2025Article
- Article
- Complete appendiceal intussusception and appendiceal mucinous tumor: A case report and review of literature.World journal of gastrointestinal surgery · 2025Article
- [Short summary of the new S2k guidelines on low-grade appendiceal mucinous neoplasms-What is important for the clinical practice?]Chirurgie (Heidelberg, Germany) · 2025Review
- Analysis of clinicopathological characteristics and prognosis of appendiceal neuroendocrine tumors: a retrospective cohort study based on the SEER database.Translational cancer research · 2025Article
- Survival outcomes of local versus radical resection for appendiceal neuroendocrine tumors: a population-based study.Translational cancer research · 2025Article
- A case of well-differentiated neuroendocrine tumor of the appendix in a 14-year-old male adolescent clinically presented with features of acute appendicitis: A case report and literature review.International journal of surgery case reports · 2025Article
- The incidence of incidental neoplasia in pathology samples of patient who underwent appendectomy due to acute appendicitis. A single center experience: 6446 cases.Irish journal of medical science · 2024Article
- Survival among 148 patients with an incidentally detected appendiceal tumours at surgery for acute appendicitis: a population-based cohort follow-up study.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2024Article
Corrections and comments
- Erratum issuedErratum.2024
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNeoplasms of the vermiform appendix are rare. They comprise a heterogeneous group of entities requiring differentkinds of treatment.
methodsThis review is based on publications retrieved by a selective literature search in the PubMed, Embase, and Cochranedatabases.
results0.5% of all tumors of the gastrointestinal tract arise in the appendix. Their treatment depends on their histopathologicalclassification and tumor stage. The mucosal epithelium gives rise to adenomas, sessile serrated lesions, adenocarcinomas,goblet-cell adenocarcinomas, and mucinous neoplasms. Neuroendocrine neoplasms originate in neuroectodermal tissue. Adenomasof the appendix can usually be definitively treated by appendectomy. Mucinous neoplasms, depending on their tumorstage, may require additional cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemoperfusion (HIPEC). Adeno -carcinomas and goblet-cell adenocarcinomas can metastasize via the lymphatic vessels and the bloodstream and should thereforebe treated by oncological right hemicolectomy. Approximately 80% of neuroendocrine tumors are less than 1 cm in diameterwhen diagnosed and can therefore be adequately treated by appendectomy; right hemicolectomy is recommended if the patienthas risk factors for metastasis via the lymphatic vessels. Systemic chemotherapy has not been shown to be beneficial forappendiceal neoplasms in prospective, randomized trials; it is recommended for adenocarcinomas and goblet-cell adenocarcinomasof stage III or higher, in analogy to the treatment of colorectal carcinoma.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.