Evidence map›Paper›PMID 37282582›Full record

ArticleJournal of neurotrauma2023

Tau Positron Emission Tomography and Neurocognitive Function Among Former Professional American-Style Football Players.

Maeva Dhaynaut, Rachel Grashow, Marc D Normandin, Ona Wu, Dean Marengi, Douglas P Terry, Justin S Sanchez, Marc G Weisskopf, Frank E Speizer, Herman A Taylor and 9 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurotrauma, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Review
  3. Molecular neurodegeneration · 2025
    Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 7 institutions in 2 countries.

Maeva DhaynautGordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Rachel GrashowDepartment of Environmental Health, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USA.
Marc D NormandinGordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Ona WuAthinoula A. Martinos Centre for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, Massachusetts, USA.
Dean MarengiDepartment of Environmental Health, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USA.
Douglas P TerryVanderbilt Sports Concussion Center, Department of Neurological Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Justin S SanchezGordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Marc G WeisskopfDepartment of Environmental Health, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USA.
Frank E SpeizerDepartment of Environmental Health, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USA.
Herman A TaylorFootball Players Health Study at Harvard University, Harvard Medical School, Boston, Massachusetts, USA.
Nicolas J GuehlGordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Sudha SeshadriThe Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, UTHSA, San Antonio, Texas, USA.
Alexa BeiserNHLBI's Framingham Heart Study, Framingham, Massachusetts, USA.
Daniel H DaneshvarDepartment of Physical Medicine and Rehabilitation, Spaulding Rehabilitation Hospital, Charlestown, Massachusetts 02129, USA.
Keith JohnsonGordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Grant L IversonDepartment of Physical Medicine and Rehabilitation, Spaulding Rehabilitation Hospital, Charlestown, Massachusetts 02129, USA.
Ross ZafonteFootball Players Health Study at Harvard University, Harvard Medical School, Boston, Massachusetts, USA.
Georges El FakhriGordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Aaron L BaggishFootball Players Health Study at Harvard University, Harvard Medical School, Boston, Massachusetts, USA.
Harvard University · USAthinoula A. Martinos Center for Biomedical Imaging · USBoston University · USBrigham and Women's Hospital · USInstitute for Neurodegenerative Disorders · USNeurological Surgery · USSpaulding Rehabilitation Hospital · US

Funding

Unified Joint Statistical Reconstruction of PET & MRP41EB022544 · NIBIB · YALE UNIVERSITY · PI Georges El Fakhri · 2017 to 2026
$14.8M
NIBIB NIH HHS P41 EB022544
6 · The paper itself

Abstract

American-style football (ASF) players experience repetitive head impacts that may result in chronic traumatic encephalopathy neuropathological change (CTE-NC). At present, a definitive diagnosis of CTE-NC requires the identification of localized hyperphosphorylated Tau (p-Tau) after death via immunohistochemistry. Some studies suggest that positron emission tomography (PET) with the radiotracer [

Indexed as

Brain ConcussionChronic Traumatic EncephalopathyFootballAdultAmyloid beta-PeptidesBrainHumansMaleMiddle AgedPositron-Emission Tomographytau ProteinsAmyloid beta-Peptidestau ProteinsconcussionfootballFTPPETTBI

Identifiers

PMID37282582
PMCPMC10458363
OpenAlexW4379598210

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.