Evidence map›Paper›PMID 37282564›Full record

ArticleEuropean psychiatry : the journal of the Association of European Psychiatrists2023

SARS-CoV-2 and risk of psychiatric hospital admission and use of psychopharmaceuticals: A nationwide registry study of 4,585,083 adult Danish citizens.

Valdemar Rømer, Pradeesh Sivapalan, Josefin Eklöf, Susanne D Nielsen, Zitta B Harboe, Tor Biering-Sørensen, Theis Itenov, Jens-Ulrik S Jensen

Abstract read
In one paragraph

Article in European psychiatry : the journal of the Association of European Psychiatrists, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. The impact of social distancing on mental health during the COVID-19 pandemic: a nationwide study of 4.6 million Danish adults.European psychiatry : the journal of the Association of European Psychiatrists · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Valdemar RømerSection of Respiratory Medicine, Herlev-Gentofte University Hospital, Hellerup, Denmark.ORCID 0000-0002-1814-7639
Pradeesh SivapalanSection of Respiratory Medicine, Herlev-Gentofte University Hospital, Hellerup, Denmark.ORCID 0000-0002-8620-3655
Josefin EklöfSection of Respiratory Medicine, Herlev-Gentofte University Hospital, Hellerup, Denmark.ORCID 0000-0003-3739-7526
Susanne D NielsenDepartment of Infectious Diseases, University Hospital of Copenhagen, Copenhagen, Denmark.ORCID 0000-0001-6391-7455
Zitta B HarboeDepartment of Pulmonary and Infectious Diseases, University Hospital of Copenhagen, North Zealand, Denmark.ORCID 0000-0001-5552-0095
Tor Biering-SørensenDepartment of Cardiology, Herlev-Gentofte University Hospital, Hellerup, Denmark.ORCID 0000-0003-4209-2778
Theis ItenovCentre for Health and Infectious Diseases Research (CHIP), University Hospital of Copenhagen, Copenhagen, Denmark.ORCID 0000-0002-1204-3636
Jens-Ulrik S JensenSection of Respiratory Medicine, Herlev-Gentofte University Hospital, Hellerup, Denmark.ORCID 0000-0003-4036-0521

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCurrent evidence on the risk of admission- or medication-requiring psychiatric sequelae of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is limited to selected populations, short durations, and loss to follow-up. This study examined if SARS-CoV-2 infection was associated with increased long-term risk of psychiatric admissions and

methodsAdults (≥18 years) were assigned to either the control or SARS-CoV-2 group based on polymerase chain reaction (PCR) tests between 1 January 2020 and 27 November 2021. Infected subjects were matched 1:5 to control subjects by propensity score. Incidence rate ratios (IRRs) were calculated. Adjusted Cox regression was applied to the unmatched population with SARS-CoV-2 infection as a time-dependent covariate. Follow-up time was 12 months or until the end of the study.

resultsA total of 4,585,083 adults were included in the study. Approximately 342,084 had a PCR-confirmed SARS-CoV-2 infection and were matched 1:5 with 1,697,680 controls. The IRR for psychiatric admission was 0.79 in the matched population (95% confidence interval [CI]: 0.73-0.85,

conclusionsWe found a signal of increased use of psychoactive medication, specifically benzodiazepines, among SARS-CoV-2-positive persons, but the risk of psychiatric admissions did not increase.

Indexed as

COVID-19SARS-CoV-2AdultDenmarkHospitals, PsychiatricHumansPsychotropic DrugsRegistriesPsychotropic DrugsLong COVIDpsychiatrypsychopharmaceuticalsSARS-CoV-2

Identifiers

PMID37282564
PMCPMC10305760

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.