Evidence map›Paper›PMID 37282447›Full record

ArticleSaudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association

Frequency and predictive factors for spontaneous normalization of anti-tissue transglutaminase-IgA serology among Saudi children with type 1 diabetes mellitus: A cohort study.

Ahmed Al Sarkhy, Ali Al Hassan, Heba Assiri, Hayfa Alabdulkarim, Noor AlAnazi, Nawaf Alshammari, Najla AlOtaibi, Mona Al Asmi, Asaad Assiri, Reem Al-Khalifah and 2 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. The when, why and whom to biopsy of type 1 diabetes mellitus children with positive anti-tissue transglutaminase serology.Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Ahmed Al SarkhyDepartment of Pediatrics, Gastroenterology Unit, College of Medicine, King Saud University; Department of Pediatrics, Prince Abdullah Bin Khalid Celiac Disease Research Chair, King Saud University, Riyadh, Saudi Arabia.
Ali Al HassanDepartment of Pediatrics, Gastroenterology Unit, College of Medicine, King Saud University, Riyadh; Department of Pediatrics, Maternity and Childhood Hospital, Ahsa, Saudi Arabia.
Heba AssiriDepartment of Pediatrics, Gastroenterology Unit, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
Hayfa AlabdulkarimDepartment of Pediatrics, Gastroenterology Unit, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
Noor AlAnaziDepartment of Pediatrics, Gastroenterology Unit, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
Nawaf AlshammariDepartment of Pediatrics, Gastroenterology Unit, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
Najla AlOtaibiDepartment of Pediatrics, Gastroenterology Unit, College of Medicine, King Saud University, Riyadh; Department of Pediatrics, College of Medicine, Majmaah University, Majmaah, Saudi Arabia.
Mona Al AsmiDepartment of Pediatrics, Gastroenterology Unit, College of Medicine, King Saud University; Department of Pediatrics, Prince Abdullah Bin Khalid Celiac Disease Research Chair, King Saud University, Riyadh, Saudi Arabia.
Asaad AssiriDepartment of Pediatrics, Gastroenterology Unit, College of Medicine, King Saud University; Department of Pediatrics, Prince Abdullah Bin Khalid Celiac Disease Research Chair, King Saud University, Riyadh, Saudi Arabia.
Reem Al-KhalifahDepartment of Pediatrics, Division of Endocrinology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
Shaik Shaffi AhamedDepartment of Family and Community Medicine, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
Mohammad El MouzanDepartment of Pediatrics, Gastroenterology Unit, College of Medicine, King Saud University; Department of Pediatrics, Prince Abdullah Bin Khalid Celiac Disease Research Chair, King Saud University, Riyadh, Saudi Arabia.
King Saud University · SAPrince Mohammed bin Abdulaziz Hospital · SA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Celiac serology can be transiently elevated in patients with type 1 diabetes mellitus (T1DM) and normalized despite gluten consumption. This study aimed to identify the frequency and predictive factors of spontaneous normalization of anti-tissue transglutaminase (anti-TTG-IgA) antibodies in these patients. Methods: The charts of all patients (≤18 years) with T1DM were retrospectively reviewed from 2012 to 2021 at a tertiary care center in Riyadh, Saudi Arabia. The following data were collected: clinical characteristics of the participants, anti-TTG-IgA-immunoglobulin (Ig) A antibody, and histological findings. The outcome of positive anti-TTG-IgA-IgA in patients with T1DM and the predictive factors for spontaneous normalization were investigated. Results: Of the 1,006 patients with T1DM, 138 (13.7%) had elevated anti-TTG-IgA antibodies, celiac disease was diagnosed in 58/138 (42%) patients, spontaneous normalization of anti-TTG-IgA was observed in 65 (47.1%) patients, and fluctuating anti-TTG-IgA antibodies were seen in 15 (10.9%) patients. The patients with anti-TTG-IgA levels at 3-10 times the upper normal limits (UNL), and those with levels ≥10 times UNL were less likely to have spontaneous normalization of anti-TTG-IgA compared to patients with levels at 1-3 times UNL (hazard ratio [HR] = 0.28, 95% confidence interval [Cl] = 0.13-0.61, P = 0.001, and HR = 0.03, 95% Cl = 0.00-0.19, P < 0.001, respectively). Conclusion: Asymptomatic patients with T1DM with mild elevation of anti-TTG-IgA need not be rushed for invasive endoscopy or exposed to an un-needed gluten-free diet but should rather have a regular follow-up of their celiac serology.

Indexed as

Celiac DiseaseDiabetes Mellitus, Type 1AutoantibodiesChildCohort StudiesHumansImmunoglobulin ARetrospective StudiesSaudi ArabiaTransglutaminasesAutoantibodiesImmunoglobulin ATransglutaminasesAnti-TTG-IgA antibodiesceliac diseasechildrenresolutiontype 1 diabetes mellitus

Identifiers

PMID37282447
PMCPMC10645001
OpenAlexW4379051883

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.