Evidence map›Paper›PMID 37282374›Full record

ArticleJournal of stroke2023

Recanalization Therapies for Large Vessel Occlusion Due to Cervical Artery Dissection: A Cohort Study of the EVA-TRISP Collaboration.

Christopher Traenka, Johannes Lorscheider, Christian Hametner, Philipp Baumgartner, Jan Gralla, Mauro Magoni, Nicolas Martinez-Majander, Barbara Casolla, Katharina Feil, Rosario Pascarella and 24 more

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Article in Journal of stroke, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Observational
  2. Observational
  3. Article
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  5. Review
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

34 authors.

Christopher TraenkaDepartment of Neurology and Stroke Center, University Hospital Basel and University of Basel, Basel, Switzerland.
Johannes LorscheiderDepartment of Neurology and Stroke Center, University Hospital Basel and University of Basel, Basel, Switzerland.
Christian HametnerDepartment of Neurology, University Hospital Heidelberg, Heidelberg, Germany.
Philipp BaumgartnerDivision of Vascular Neurology and Neurorehabilitation, Department of Neurology, University Hospital of Zurich, University of Zurich, Zurich, Switzerland.
Jan GrallaInstitute of Diagnostic and Interventional Neuroradiology University Hospital Bern, University of Bern, Bern, Switzerland.
Mauro MagoniASST Spedali Civili, Neurologia Vascolare, Brescia, Italy.
Nicolas Martinez-MajanderNeurology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Barbara CasollaUniv. Lille, Inserm, CHU Lille, U1172 - LilNCog - Lille Neuroscience & Cognition, Lille, France.
Katharina FeilDepartment of Neurology, Ludwig Maximilian University (LMU), Munich, Germany.
Rosario PascarellaNeuroradiology Unit, Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia, Reggio Emilia, Italy.
Panagiotis PapanagiotouDepartment of Neurology, Klinikum Bremen-Ost, Bremen, Germany.
Annika NordanstigDepartment of Neurology, Sahlgrenska University Hospital and Department of Clinical Neuroscience Institute for Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.
Visnja PadjenUniversity of Belgrade, Faculty of Medicine, Neurology Clinic, University Clinical Centre of Serbia, Belgrade, Serbia.
Carlo W CeredaStroke Center, Department of Neurology, Neurocenter of Southern Switzerland, Ente Ospedaliero Cantonale (EOC), Lugano, Switzerland.
Marios PsychogiosDepartment of Neurology and Stroke Center, University Hospital Basel and University of Basel, Basel, Switzerland.
Christian H NolteKlinik für Neurologie mit experimenteller Neurologie, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Germany and Center for Stroke Research Berlin (CSB), Charité-Universitätsmedizin Berlin, Germany.
Andrea ZiniIRCCS Istituto delle Scienze Neurologiche di Bologna, Department of Neurology and Stroke Center, Maggiore Hospital, Bologna, Italy.
Patrik MichelStroke Service, Neurology Service, Lausanne University Hospital, Lausanne, Switzerland.
Yannick BéjotDepartment of Neurology, University Hospital Dijon, Dijon, France.
Andreas KastrupDepartment of Neurology, Klinikum Bremen-Ost, Bremen, Germany.
Marialuisa ZeddeNeurology Unit, Stroke Unit, Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia, Reggio Emilia, Italy.
Georg KägiDepartment of Neurology, Kantonsspital St. Gallen, St. Gallen, Switzerland.
Lars KellertDepartment of Neurology, Ludwig Maximilian University (LMU), Munich, Germany.
Hilde HenonUniv. Lille, Inserm, CHU Lille, U1172 - LilNCog - Lille Neuroscience & Cognition, Lille, France.
Sami CurtzeNeurology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Alessandro PezziniDepartment of Clinical and Experimental Sciences, Neurology Clinic, University of Brescia, Brescia, Italy.
Marcel ArnoldDepartment of Neurology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Susanne WegenerDivision of Vascular Neurology and Neurorehabilitation, Department of Neurology, University Hospital of Zurich, University of Zurich, Zurich, Switzerland.
Peter RinglebDepartment of Neurology, University Hospital Heidelberg, Heidelberg, Germany.
Turgut TatlisumakDepartment of Neurology, Sahlgrenska University Hospital and Department of Clinical Neuroscience Institute for Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.
Paul J NederkoornDepartment of Neurology, Amsterdam UMC location University of Amsterdam, Amsterdam, The Netherlands.
Stefan T EngelterDepartment of Neurology and Stroke Center, University Hospital Basel and University of Basel, Basel, Switzerland.
Henrik GensickeDepartment of Neurology and Stroke Center, University Hospital Basel and University of Basel, Basel, Switzerland.
EVA-TRISP CollaboratorsDepartment of Neurology and Stroke Center, University Hospital Basel and University of Basel, Basel, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeThis study aimed to investigate the effect of endovascular treatment (EVT, with or without intravenous thrombolysis [IVT]) versus IVT alone on outcomes in patients with acute ischemic stroke (AIS) and intracranial large vessel occlusion (LVO) attributable to cervical artery dissection (CeAD).

methodsThis multinational cohort study was conducted based on prospectively collected data from the EVA-TRISP (EndoVAscular treatment and ThRombolysis for Ischemic Stroke Patients) collaboration. Consecutive patients (2015-2019) with AIS-LVO attributable to CeAD treated with EVT and/or IVT were included. Primary outcome measures were (1) favorable 3-month outcome (modified Rankin Scale score 0-2) and (2) complete recanalization (thrombolysis in cerebral infarction scale 2b/3). Odds ratios with 95% confidence intervals (OR [95% CI]) from logistic regression models were calculated (unadjusted, adjusted). Secondary analyses were performed in the patients with LVO in the anterior circulation (LVOant) including propensity score matching.

resultsAmong 290 patients, 222 (76.6%) had EVT and 68 (23.4%) IVT alone. EVT-treated patients had more severe strokes (National Institutes of Health Stroke Scale score, median [interquartile range]: 14 [10-19] vs. 4 [2-7], P<0.001). The frequency of favorable 3-month outcome did not differ significantly between both groups (EVT: 64.0% vs. IVT: 86.8%; ORadjusted 0.56 [0.24-1.32]). EVT was associated with higher rates of recanalization (80.5% vs. 40.7%; ORadjusted 8.85 [4.28-18.29]) compared to IVT. All secondary analyses showed higher recanalization rates in the EVT-group, which however never translated into better functional outcome rates compared to the IVT-group.

conclusionWe observed no signal of superiority of EVT over IVT regarding functional outcome in CeAD-patients with AIS and LVO despite higher rates of complete recanalization with EVT. Whether pathophysiological CeAD-characteristics or their younger age might explain this observation deserves further research.

Indexed as

Cervical artery dissectionEndovascular treatmentStrokeThrombolysis

Identifiers

PMID37282374
PMCPMC10250869

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.