ArticleEye and vision (London, England)2023
Choroidal vasculature act as predictive biomarkers of long-term ocular elongation in myopic children treated with orthokeratology: a prospective cohort study.
Article in Eye and vision (London, England), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Effect of Lutein Ester Supplement on Choroidal Thickness in Children: A Randomized Controlled Trial.Translational vision science & technology · 2025Trial
- Anatomical and Transcriptional Alterations in the Mouse Choroid Induced by All-Trans Retinoic Acid.Investigative ophthalmology & visual science · 2026Article
- Short-Term Effects of Orthokeratology Treatment Zone Decentration on Choroidal Thickness and Vasculature.Translational vision science & technology · 2026Article
- Evaluation of the choroidal structural and vasculature changes following COVID-19 infection and vaccination using optical coherence tomography angiography.International journal of retina and vitreous · 2026Article
- Long-term effects of orthokeratology on moderate myopia progression in children: A 3-year prospective study.Experimental and therapeutic medicine · 2026Article
- Association between first-year axial elongation and 10-year myopia progression in children wearing orthokeratology lenses: a ten-year longitudinal study.Frontiers in cell and developmental biology · 2026Article
- Short-Term Choroidal and Retinal Structural Changes in Myopic Children Treated with 0.05% Atropine.Clinical ophthalmology (Auckland, N.Z.) · 2026Article
- The Relationship of Photopic and Mesopic Contrast Sensitivity to Retinal-Choroidal Structural Characteristics in Low-to-Moderate and High Myopia.Translational vision science & technology · 2025Article
- One-Month Changes in Choroidal Vascularity Index of Medium Vessel Layer in Children with Myopia Wearing Orthokeratology Lenses: a Predictor for One-Year Changes in Axial Length.Ophthalmology and therapy · 2025Article
- IMI-Interventions for Controlling Myopia Onset and Progression 2025.Investigative ophthalmology & visual science · 2025Review
- Choroidal Features of Cynomolgus Macaques in Relation to Age and Axial Length.Investigative ophthalmology & visual science · 2025Article
- Comparing the effects of orthokeratology lenses and highly aspherical lenslets on axial length in myopic anisometropia.BMC ophthalmology · 2025Article
- Choroidal response to optical defocus as a potential surrogate marker for myopia control effect.International journal of ophthalmology · 2025Article
- Investigation into the Therapeutic Efficacy and Inflammatory Modulatory Effects of the Combined Use of 0.01% Atropine Eye Drops and Orthokeratology Lenses in the Management of Myopia Among Adolescent Patients.Journal of inflammation research · 2025Article
- Nomogram-based model to predict prognosis in anisometropic amblyopia.Frontiers in medicine · 2025Article
- Microcirculatory parameters as risk factors for predicting progression of posterior staphyloma in highly myopic eyes: a case-control study.Eye and vision (London, England) · 2024Article
- Biomarkers: Promising Tools Towards the Diagnosis, Prognosis, and Treatment of Myopia.Journal of clinical medicine · 2024Review
- VEGFA may be a potential marker of myopic choroidal thickness and vascular density changes.Scientific reports · 2024Article
- Systematic Review of Myopia Progression after Cessation of Optical Interventions for Myopia Control.Journal of clinical medicine · 2023Review
- A narrative review on orthokeratology for myopia control: Lens design, combination therapies, and clinical management.Taiwan journal of ophthalmologyReview
Corrections and comments
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Authors and funding
14 authors.
Funding
Abstract
backgroundDespite receiving orthokeratology (ortho-k), the efficacy of retarding ocular elongation during myopia varies among myopic children. The current study aimed to investigate the early changes of choroidal vasculature at one month after ortho-k treatment and its association with one-year ocular elongation, as well as the role of such choroidal responses in predicting the one-year control efficacy of ortho-k treatment.
methodsA prospective cohort study was conducted in myopic children treated with ortho-k. Myopic children aged between 8 and 12 years who were willing to wear ortho-k lenses were recruited consecutively from the Eye Hospital of Wenzhou Medical University. Subfoveal choroidal thickness (SFCT), submacular total choroidal luminal area (LA), stromal area (SA), choroidal vascularity index (CVI), choriocapillaris flow deficit (CcFD) were evaluated by optical coherence tomography (OCT) and OCT angiography over a one-year period.
resultsFifty eyes from 50 participants (24 males) who finished one-year follow-ups as scheduled were included, with a mean age of 10.31 ± 1.45 years. The one-year ocular elongation was 0.19 ± 0.17 mm. The LA (0.03 ± 0.07 mm
conclusionsChoroidal vasculature is associated with ocular elongation during ortho-k treatment. Ortho-k treatment induces increases in choroidal vascularity and choroidal thickness as early as one month. Such early changes can act as predictive biomarkers of myopia control efficacy over a long term. The utilization of these biomarkers may help clinicians identify children who can benefit from ortho-k treatment, and thus has critical implications for the management strategies towards myopia control.
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