Evidence map›Paper›PMID 37280624›Full record

ArticleVirology journal2023

Phylogenetic characterization of canine distemper virus from stray dogs in Kathmandu Valley.

Prajwol Manandhar, Rajindra Napit, Saman M Pradhan, Pragun G Rajbhandari, Jessie A Moravek, Pranav R Joshi, Rima D Shrestha, Dibesh Karmacharya

Open access · goldAbstract read
In one paragraph

Article in Virology journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Prajwol ManandharCenter for Molecular Dynamics Nepal, Thapathali, Kathmandu, Nepal. prajwol.f.manandhar@gmail.com.
Rajindra NapitCenter for Molecular Dynamics Nepal, Thapathali, Kathmandu, Nepal.
Saman M PradhanCenter for Molecular Dynamics Nepal, Thapathali, Kathmandu, Nepal.
Pragun G RajbhandariCenter for Molecular Dynamics Nepal, Thapathali, Kathmandu, Nepal.
Jessie A MoravekCenter for Molecular Dynamics Nepal, Thapathali, Kathmandu, Nepal.
Pranav R JoshiVet for Your Pet Animal Hospital, Gapali, Bhaktapur, Nepal.
Rima D ShresthaKathmandu Animal Hospital and Research Centre, Thapathali, Kathmandu, Nepal.
Dibesh KarmacharyaCenter for Molecular Dynamics Nepal, Thapathali, Kathmandu, Nepal. dibesh@cmdn.org.
Center for Molecular Dynamics - Nepal · NP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Canine distemper is a highly contagious, often fatal disease caused by canine distemper virus (CDV) in domestic dogs and wild carnivores. The virus has caused mass epidemics in both wild and captive carnivores of high conservation value such as tigers, lions and leopards. Hence, understanding and managing CDV outbreaks is particularly important in Nepal, which is home to many species of threatened wild carnivores including tigers, leopards, snow leopards, dholes and wolves, and also contains a large population of stray dogs. Previous studies have suggested that CDV may pose a threat to wild carnivores, but there have not been any studies characterizing the genetic strains of the virus circulating in Nepal's carnivores. We collected invasive and non-invasive biological samples from stray dogs in Kathmandu Valley and genetically characterized the strains of CDV in the dogs to belong to the Asia-5 lineage by using phylogenetic analysis. The same lineage also contained CDV strains sequenced from dogs, civets, red panda and lions in India. Based on our phylogenetic analysis, we think it is likely that CDV is maintained through sylvatic cycle among sympatric carnivores allowing the recurring spillovers and outbreaks. It is crucial to prevent the virus transmission from reservoir hosts to other species, especially threatened populations of large carnivores in Nepal. Hence, we recommend for regular surveillance of CDV targeting wild carnivores in addition to the domestic dogs.

Indexed as

CarnivoraDistemperDistemper Virus, CanineLionsTigersAnimalsDogsPhylogenyCanine distemper virusDisease spilloverDomestic dogsOne healthWild carnivores

Identifiers

PMID37280624
PMCPMC10245400
OpenAlexW4379536246

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.