Evidence map›Paper›PMID 37280587›Full record

ReviewMicrobial cell factories2023

Bioactive compounds and biomedical applications of endophytic fungi: a recent review.

Amr H Hashem, Mohamed S Attia, Eslam K Kandil, Mahmoud M Fawzi, Ahmed S Abdelrahman, Mohamed S Khader, Mohamed A Khodaira, Abdallah E Emam, Mohamed A Goma, Amer M Abdelaziz

Erratum issuedAbstract readReview
In one paragraph

Review in Microbial cell factories, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 85 papers.

0numbers the graph read from it
0cells of the map it votes in
85citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

85 citing papers in PubMed.

  1. Endophytic Fungi from WildJournal of fungi (Basel, Switzerland) · 2026
    Article
  2. Chemical Constituents of the Endophytic FungusMolecules (Basel, Switzerland) · 2026
    Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. ROS-CaArchives of microbiology · 2026
    Article
  10. Review
  11. Review
  12. Article
  13. Review
  14. Review
  15. Article
  16. Article
  17. Chemical and Biological Investigation of the EndophyticJournal of fungi (Basel, Switzerland) · 2026
    Article
  18. Article
  19. Article
  20. Review

25 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Amr H HashemBotany and Microbiology Department, Faculty of Science, Al-Azhar University, Cairo, Egypt. amr.hosny86@azhar.edu.eg.
Mohamed S AttiaBotany and Microbiology Department, Faculty of Science, Al-Azhar University, Cairo, Egypt. drmohamedsalah92@azhar.edu.eg.
Eslam K KandilBotany and Microbiology Department, Faculty of Science, Al-Azhar University, Cairo, Egypt.
Mahmoud M FawziBotany and Microbiology Department, Faculty of Science, Al-Azhar University, Cairo, Egypt.
Ahmed S AbdelrahmanBotany and Microbiology Department, Faculty of Science, Al-Azhar University, Cairo, Egypt.
Mohamed S KhaderBotany and Microbiology Department, Faculty of Science, Al-Azhar University, Cairo, Egypt.
Mohamed A KhodairaBotany and Microbiology Department, Faculty of Science, Al-Azhar University, Cairo, Egypt.
Abdallah E EmamBotany and Microbiology Department, Faculty of Science, Al-Azhar University, Cairo, Egypt.
Mohamed A GomaBotany and Microbiology Department, Faculty of Science, Al-Azhar University, Cairo, Egypt.
Amer M AbdelazizBotany and Microbiology Department, Faculty of Science, Al-Azhar University, Cairo, Egypt. amermorsy@azhar.edu.eg.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human life has been significantly impacted by the creation and spread of novel species of antibiotic-resistant bacteria and virus strains that are difficult to manage. Scientists and researchers have recently been motivated to seek out alternatives and other sources of safe and ecologically friendly active chemicals that have a powerful and effective effect against a wide variety of pathogenic bacteria as a result of all these hazards and problems. In this review, endophytic fungi and their bioactive compounds and biomedical applications were discussed. Endophytes, a new category of microbial source that can produce a variety of biological components, have major values for study and broad prospects for development. Recently, endophytic fungi have received much attention as a source for new bioactive compounds. In addition, the variety of natural active compounds generated by endophytes is due to the close biological relationship between endophytes and their host plants. The bioactive compounds separated from endophytes are usually classified as steroids, xanthones, terpenoids, isocoumarins, phenols, tetralones, benzopyranones and enniatines. Moreover, this review discusses enhancement methods of secondary metabolites production by fungal endophytes which include optimization methods, co-culture method, chemical epigenetic modification and molecular-based approaches. Furthermore, this review deals with different medical applications of bioactive compounds such as antimicrobial, antiviral, antioxidant and anticancer activities in the last 3 years.

Indexed as

Anti-Infective AgentsFungiAnti-Bacterial AgentsEndophytesHumansPlantsAnti-Bacterial AgentsAnti-Infective AgentsAnticancer activityAntimicrobial activityAntioxidant activityAntiviral activityFungal endophytesMedicinal plants

Identifiers

PMID37280587
PMCPMC10243280

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.