ArticleBMC pediatrics2023
Positivity rate, trend and associated risk factors of mother-to-child transmission of HIV among HIV-exposed infants.
Article in BMC pediatrics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
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Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 16 citations in OpenAlex.
- Magnitude and risk factors of mother-to-child transmission of HIV among HIV-exposed infants after Option B+ implementation in Ethiopia: a systematic review and meta-analysis.AIDS research and therapy · 2024Pooled it
- Time-Trend, Regional and National Prevalence of Vertical Transmission of HIV-1 in Sub-Saharan Africa: A Systematic Review and Meta-Analysis.Journal of primary care & community healthPooled it
- HIV Status and Its Associated Factors of Children Born to HIV-Positive Mothers on ART at Gambella Public Hospitals, South West Ethiopia, 2024.AIDS and behavior · 2026Article
- HIV positivity rate, mother-to-child transmission and associated factors among HIV exposed infants in Western Ethiopia: a cross-sectional study.BMC pediatrics · 2026Article
- Predicting early infant diagnosis (EID) results for HIV exposed infants in a resource-limited setting using machine learning models: evidence from Amhara Public Health Institute data (2024/2025).BMC infectious diseases · 2026Article
- HIV-1 drug resistance among pregnant and breastfeeding mothers and its association with paediatric HIV infections in the Dolutegravir era in Uganda.The Journal of antimicrobial chemotherapy · 2026Article
- Analysis of Risk Factors for High versus Low HIV Exposure in Neonates and Development of a Predictive Nomogram Model.Infection and drug resistance · 2026Article
- HIV vertical transmission linked to virological failure in pregnant women on ART.AIDS research and therapy · 2025Article
- Efficacy and safety of an Albuvirtide-based regimen for preventing mother-to-child transmission of multidrug-resistant HIV: a case report.BMC pregnancy and childbirth · 2025Article
- The progress of mother-to-child transmission of Human Immunodeficiency Virus (HIV) after Dolutegravir (DTG) optimization program: evidence from a multicenter cohort study in Ethiopia.BMC public health · 2024Article
- Residual transmission of HIV infection from mother to child in the Atlantic and littoral departments in Benin.BMC pediatrics · 2024Article
- Article
- Effect of Dolutegravir-Based First-Line Antiretroviral Therapy on Mother-to-Child Transmission of HIV Among HIV-Exposed Infants in Ethiopia: a Before-and-After Study.HIV/AIDS (Auckland, N.Z.) · 2024Article
- Patient Satisfaction with Antiretroviral Therapy Services in Hadiya Zone, Central Ethiopia Using the Donebidean Model: A Time-Motion Study.Patient related outcome measures · 2024Article
- Adherence to Nevirapine Prophylaxis and Its Predictors Among HIV-Exposed Infants Aged 0 to 6 months in Western Uganda: A Cross-Sectional Study.Sage open pediatricsArticle
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMother-To-Child-Transmission (MTCT) of Human Immunodeficiency Virus (HIV) occurs during pregnancy, delivery and breastfeeding, and cause infection among several new-borns. However, there is limited recent evidence on the burden of MTCT of HIV in Ethiopia from a large-scale data. Thus, this study aimed to determine the positivity rate, trend and associated risk factors of MTCT among HIV-exposed infants. METHODOLOGY: A cross-sectional study was conducted among 5,679 infants whose specimen referred to Ethiopian Public Health Institute HIV referral laboratory for Early Infant Diagnosis (EID) from January 01, 2016, to December 31, 2020. Data were extracted from the national EID database. Frequencies and percentages were used to summarize the data on characteristics of infants. Logistic regression analysis was employed to identify factors associated with positivity rate of MTCT of HIV. Level of significance was set at 5%.
resultsThe mean age of the infants was 12.6 (± 14.6) weeks with an age range of 4 to 72 weeks. Half of the infants (51.4%) were female. The positivity rate of MTCT decreased from 2.9% in 2016 to 0.9% in 2020 with five-year average positivity rate of 2.6%. HIV test after six weeks (Adjusted odds ratio (AOR) = 2.7; 95% confidence interval (CI): (1.8-4.0,)); p < 0.001), absence of prevention of mother-to-child-transmission (PMTCT) service (AOR = 4.6; 95% CI: (2.9-7.4)); p = 0.001), nevirapine prophylaxis not received (AOR = 2.0; 95% CI: (1.3-3.2)); p < 0.001), and unknown ART status of the mother at delivery (AOR = 11; 95% CI: (5.5-22.1)); p < 0.001) were significantly associated with MTCT of HIV.
conclusionThe positivity rate of MTCT of HIV was showing declining tendency gradually in the study period. Strengthening PMTCT service, early HIV screening and starting ART for pregnant women, and early infant diagnosis are required to reduce the burden of HIV infection among infants exposed to HIV.
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