Evidence map›Paper›PMID 37280534›Full record

ArticleBMC infectious diseases2023

Association of plasma aflatoxin with persistent detection of oncogenic human papillomaviruses in cervical samples from Kenyan women enrolled in a longitudinal study.

Yan Tong, Philip Tonui, Omenge Orang'o, Jianjun Zhang, Titus Maina, Kapten Muthoka, John Groopman, Joshua Smith, Erin Madeen, Aaron Ermel and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC infectious diseases, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 2 countries.

Yan Tong *Department of Biostatistics and Health Data Science, Indiana University School of Medicine and Fairbanks School of Public Health, Indianapolis, IN, 46204, USA.
Philip Tonui *Department of Reproductive Health, Moi University, Eldoret, Kenya.
Omenge Orang'oDepartment of Reproductive Health, Moi University, Eldoret, Kenya.
Jianjun ZhangDepartment of Epidemiology, Fairbanks School of Public Health, Indiana University, Indianapolis, IN, 46204, USA.
Titus MainaDepartment of Molecular Biology, Maseno University, Maseno, Kenya.
Kapten MuthokaAcademic Model Providing Access to Healthcare (AMPATH), Eldoret, Kenya.
John GroopmanDepartment of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, 21205, USA.
Joshua SmithDepartment of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, 21205, USA.
Erin MadeenDepartment of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, 21205, USA.
Aaron ErmelDepartment of Medicine, Indiana University School of Medicine, Indianapolis, IN, 46204, USA.
Patrick LoehrerDepartment of Medicine, Indiana University School of Medicine, Indianapolis, IN, 46204, USA.
Darron R BrownDepartment of Medicine, Indiana University School of Medicine, Indianapolis, IN, 46204, USA. darbrow@iu.edu.
Indiana University – Purdue University Indianapolis · USJohns Hopkins University · USMoi University · KEAMPATH · KEIndiana University Health · USIndiana University School of MedicineMaseno University · KE

Funding

Tumor Microenvironment and Metastasis ProgramP30CA082709 · NCI · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI Sara K Quinney · 1999 to 2026
$59.3M
Translational Biology CoreU54CA190151 · NCI · INDIANA UNIVERSITY INDIANAPOLIS · PI BROWN, DARRON R, LOEHRER, PATRICK J. · 2014 to 2019
$3.8M
NCI NIH HHS P30 CA082709NCI NIH HHS U54 CA190151
6 · The paper itself

Abstract

backgroundCervical cancer is caused by oncogenic human papillomaviruses (HR-HPV) and is common among Kenyan women. Identification of factors that increase HR-HPV persistence is critically important. Kenyan women exposed to aflatoxin have an increased risk of HR-HPV detection in cervical specimens. This analysis was performed to examine associations between aflatoxin and HR-HPV persistence.

methodsKenyan women were enrolled in a prospective study. The analytical cohort for this analysis included 67 HIV-uninfected women (mean age 34 years) who completed at least two of three annual study visits and had an available blood sample. Plasma aflatoxin was detected using ultra-high pressure liquid chromatography (UHPLC)-isotope dilution mass spectrometry. Annual cervical swabs were tested for HPV (Roche Linear Array). Ordinal logistic regression models were fitted to examine associations of aflatoxin and HPV persistence.

resultsAflatoxin was detected in 59.7% of women and was associated with higher risk of persistent detection of any HPV type (OR = 3.03, 95%CI = 1.08-8.55, P = 0.036), HR-HPV types (OR = 3.63, 95%CI = 1.30-10.13, P = 0.014), and HR-HPV types not included in the 9-valent HPV vaccine (OR = 4.46, 95%CI = 1.13-17.58, P = 0.032).

conclusionsAflatoxin detection was associated with increased risk of HR-HPV persistence in Kenyan women. Further studies, including mechanistic studies are needed to determine if aflatoxin synergistically interacts with HR-HPV to increase cervical cancer risk.

Indexed as

HIV InfectionsPapillomavirus InfectionsUterine Cervical NeoplasmsAdultFemaleHuman Papillomavirus VirusesHumansKenyaLogistic ModelsLongitudinal StudiesPapillomaviridaeProspective StudiesAflatoxinHuman papillomavirusKenyan women

Identifiers

PMID37280534
PMCPMC10242809
OpenAlexW4379511480

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.