Evidence map›Paper›PMID 37280080›Full record

ArticleRespiratory care2023

Response to Bronchodilators Administered via Different Nebulizers in Patients With COPD Exacerbation.

Breda Cushen, Abir Alsaid, Garrett Greene, Richard W Costello

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Respiratory care, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it, 1 citations in OpenAlex.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Breda CushenDepartment of Respiratory Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland; and Department of Respiratory Medicine, Beaumont Hospital, Dublin, Ireland. bredacushen@rcsi.ie.
Abir AlsaidDepartment of Internal Medicine, King Fahd Hospital of the University, University of Dammam, Dammam, Saudi Arabia.
Garrett GreeneDepartment of Respiratory Medicine, Beaumont Hospital, Dublin, Ireland.
Richard W CostelloDepartment of Respiratory Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland; Department of Respiratory Medicine, Beaumont Hospital, Dublin, Ireland; and Clinical Research Centre, Royal College of Surgeons in Ireland, Dublin, Ireland.
Royal College of Surgeons in Ireland · IEBeaumont Hospital · IEKing Fahd Hospital of the University · SA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe recommended treatment of COPD exacerbations includes administration of short-acting bronchodilators that act to reverse bronchoconstriction, restore lung volumes, and relieve breathlessness. In vitro studies demonstrate vibrating mesh nebulizers (VMNs) provide greater drug delivery to the airway compared to standard small-volume nebulizers (SVNs). We examined whether the physiological and symptom response to nebulized bronchodilators during a COPD exacerbation differed between these 2 modes of bronchodilator delivery.

methodsSubjects hospitalized with a COPD exacerbation participated in a comparative clinical effectiveness study of 2 methods of nebulization. Using block randomization, 32 participants in this open-label trial were administered salbutamol 2.5 mg/ipratropium bromide 0.5 mg via vibrating mesh (VMN group,

resultsBaseline demographics were comparable between groups. Mean FEV

conclusionsGreater improvement in symptoms, and larger absolute change in FVC, was observed in response to equivalent doses of standard bronchodilators administered by VMN, compared to SVN, but no substantial difference in change in IC.

Indexed as

Bronchodilator AgentsPulmonary Disease, Chronic ObstructiveAdministration, InhalationAlbuterolDyspneaHumansNebulizers and VaporizersRespiratory Aerosols and DropletsAlbuterolBronchodilator Agentsbronchodilator deliverybronchodilator responseCOPD exacerbation managementexacerbations of COPDsmall-volume nebulizervibrating mesh nebulizer

Identifiers

PMID37280080
PMCPMC10589110
OpenAlexW4379513291

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.