Evidence map›Paper›PMID 37279998›Full record

ArticleRNA (New York, N.Y.)2023

Recoding UAG to selenocysteine in

Kyle S Hoffman, Christina Z Chung, Takahito Mukai, Natalie Krahn, Han-Kai Jiang, Nileeka Balasuriya, Patrick O'Donoghue, Dieter Söll

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in RNA (New York, N.Y.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.6field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Review
  3. Engineered mRNA-ribosome fusions for facile biosynthesis of selenoproteins.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  4. Tuning tRNAs for improved translation.Frontiers in genetics · 2024
    Review
  5. Review
  6. Review
  7. Biosynthesis, Engineering, and Delivery of Selenoproteins.International journal of molecular sciences · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Kyle S HoffmanDepartment of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06511, USA.
Christina Z ChungDepartment of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06511, USA.
Takahito MukaiDepartment of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06511, USA.ORCID 0000-0001-8618-598X
Natalie KrahnDepartment of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06511, USA.ORCID 0000-0003-0696-433X
Han-Kai JiangDepartment of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06511, USA.
Nileeka BalasuriyaDepartment of Biochemistry, The University of Western Ontario, London, Ontario N6A 3K7, Canada.
Patrick O'DonoghueDepartment of Biochemistry, The University of Western Ontario, London, Ontario N6A 3K7, Canada.
Dieter SöllDepartment of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06511, USA dieter.soll@yale.edu.ORCID 0000-0002-3077-8986
Yale University · USWestern University · CA

Funding

Studies of Transfer RNAR35GM122560 · NIGMS · YALE UNIVERSITY · PI SOLL, DIETER · 2017 to 2022
$5.6M
NIGMS NIH HHS R35 GM122560
6 · The paper itself

Abstract

Unique chemical and physical properties are introduced by inserting selenocysteine (Sec) at specific sites within proteins. Recombinant and facile production of eukaryotic selenoproteins would benefit from a yeast expression system; however, the selenoprotein biosynthetic pathway was lost in the evolution of the kingdom Fungi as it diverged from its eukaryotic relatives. Based on our previous development of efficient selenoprotein production in bacteria, we designed a novel Sec biosynthesis pathway in

Indexed as

Saccharomyces cerevisiaeAeromonas salmonicidaCodon, TerminatorCystineHumansNucleic Acid ConformationOrganoselenium CompoundsProtein EngineeringRNA, Transfer, CysCodon, TerminatorCystineOrganoselenium CompoundsRNA, Transfer, Cysselenocystinegenetic code expansionselenocysteineselenoproteintranslationtRNAyeast

Identifiers

PMID37279998
PMCPMC10573291
OpenAlexW4379512576

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.