Evidence map›Paper›PMID 37279751›Full record

ArticleCell reports. Medicine2023

Nucleic acid biomarkers of immune response and cell and tissue damage in children with COVID-19 and MIS-C.

Conor J Loy, Alicia Sotomayor-Gonzalez, Venice Servellita, Jenny Nguyen, Joan Lenz, Sanchita Bhattacharya, Meagan E Williams, Alexandre P Cheng, Andrew Bliss, Prachi Saldhi and 19 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports. Medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
7.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
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  6. Review
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  10. Circulating cell-free RNA signatures for the characterization and diagnosis of myalgic encephalomyelitis/chronic fatigue syndrome.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  11. Article
  12. Review
  13. Article
  14. Plasma cell-free RNA signatures of inflammatory syndromes in children.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  15. Article
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  17. Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors at 6 institutions in 1 country.

Conor J LoyMeinig School of Biomedical Engineering, Cornell University, Ithaca, NY 14850, USA.
Alicia Sotomayor-GonzalezDepartment of Laboratory Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.
Venice ServellitaDepartment of Laboratory Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.
Jenny NguyenDepartment of Laboratory Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.
Joan LenzMeinig School of Biomedical Engineering, Cornell University, Ithaca, NY 14850, USA.
Sanchita BhattacharyaBakar Computational Health Sciences Institute, University of California, San Francisco, San Francisco, CA 94143, USA.
Meagan E WilliamsChildren's National Hospital, Washington, DC 20010, USA.
Alexandre P ChengMeinig School of Biomedical Engineering, Cornell University, Ithaca, NY 14850, USA.
Andrew BlissMeinig School of Biomedical Engineering, Cornell University, Ithaca, NY 14850, USA.
Prachi SaldhiDepartment of Laboratory Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.
Noah BrazerDepartment of Laboratory Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.
Jessica StreithorstDepartment of Laboratory Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.
William SuslovicChildren's National Hospital, Washington, DC 20010, USA.
Charlotte J HsiehDivision of Pediatric Infectious Diseases and Global Health, Department of Pediatrics, University of California San Francisco, Oakland, CA 94609.
Burak BaharChildren's National Hospital, Washington, DC 20010, USA.
Nathan WoodUCSF Benioff Children's Hospital, Oakland, CA 94609, USA.
Abiodun ForesytheDepartment of Laboratory Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.
Amelia GliwaDepartment of Laboratory Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.
Kushmita BhaktaDepartment of Pediatrics, Emory University School of Medicine, Atlanta, GA, 30322, USA; Children's Healthcare of Atlanta, Atlanta, GA, 30322, USA.
Maria A PerezDepartment of Pediatrics, Emory University School of Medicine, Atlanta, GA, 30322, USA; Children's Healthcare of Atlanta, Atlanta, GA, 30322, USA.
Laila HussainiDepartment of Pediatrics, Emory University School of Medicine, Atlanta, GA, 30322, USA; Children's Healthcare of Atlanta, Atlanta, GA, 30322, USA.
Evan J AndersonDepartment of Pediatrics, Emory University School of Medicine, Atlanta, GA, 30322, USA; Children's Healthcare of Atlanta, Atlanta, GA, 30322, USA; Department of Medicine, Emory University School of Medicine, Atlanta, GA 30307, USA.
Ann ChahroudiDepartment of Pediatrics, Emory University School of Medicine, Atlanta, GA, 30322, USA; Children's Healthcare of Atlanta, Atlanta, GA, 30322, USA.
Meghan DelaneyChildren's National Hospital, Washington, DC 20010, USA; The George Washington University School of Medicine, Washington, DC 20052, USA.
Atul J ButteBakar Computational Health Sciences Institute, University of California, San Francisco, San Francisco, CA 94143, USA.
Roberta L DeBiasiChildren's National Hospital, Washington, DC 20010, USA; The George Washington University School of Medicine, Washington, DC 20052, USA.
Christina A RostadDepartment of Pediatrics, Emory University School of Medicine, Atlanta, GA, 30322, USA; Children's Healthcare of Atlanta, Atlanta, GA, 30322, USA.
Iwijn De VlaminckMeinig School of Biomedical Engineering, Cornell University, Ithaca, NY 14850, USA. Electronic address: id93@cornell.edu.
Charles Y ChiuDepartment of Laboratory Medicine, University of California, San Francisco, San Francisco, CA 94143, USA; Division of Infectious Diseases, Department of Medicine, University of California, San Francisco, San Francisco, CA 94158, USA. Electronic address: charles.chiu@ucsf.edu.
University of California, San Francisco · USEmory University · USCornell University · USChildren's National · USGeorge Washington University Hospital · USUCSF Benioff Children's Hospital · US

Funding

Yerkes National Primate Research Center Role of type-I IFN in regulating COVID-19 induced inflammation and pathogenesisP51OD011132 · OD · EMORY UNIVERSITY · PI Joon Sup Lee · 2012 to 2026
$167.0M
Discovery and clinical validation of host biomarkers of disease severity and multi-system inflammatory syndrome in children (MIS-C) with Covid-19R33HD105618 · NICHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHIU, CHARLES YEN, DE VLAMINCK, IWIJN · 2023 to 2023
$3.2M
Uncovering associations of variant infection with COVID-19 disease severity in childrenR61HD105618 · NICHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHIU, CHARLES YEN, DE VLAMINCK, IWIJN · 2021 to 2022
$3.2M
NICHD NIH HHS R33 HD105618NICHD NIH HHS R61 HD105618NIH HHS P51 OD011132
6 · The paper itself

Abstract

Differential host responses in coronavirus disease 2019 (COVID-19) and multisystem inflammatory syndrome in children (MIS-C) remain poorly characterized. Here, we use next-generation sequencing to longitudinally analyze blood samples from pediatric patients with COVID-19 or MIS-C across three hospitals. Profiling of plasma cell-free nucleic acids uncovers distinct signatures of cell injury and death between COVID-19 and MIS-C, with increased multiorgan involvement in MIS-C encompassing diverse cell types, including endothelial and neuronal cells, and an enrichment of pyroptosis-related genes. Whole-blood RNA profiling reveals upregulation of similar pro-inflammatory pathways in COVID-19 and MIS-C but also MIS-C-specific downregulation of T cell-associated pathways. Profiling of plasma cell-free RNA and whole-blood RNA in paired samples yields different but complementary signatures for each disease state. Our work provides a systems-level view of immune responses and tissue damage in COVID-19 and MIS-C and informs future development of new disease biomarkers.

Indexed as

Cell-Free Nucleic AcidsCOVID-19Nucleic AcidsBiomarkersChildHumansRNASystemic Inflammatory Response SyndromeBiomarkersCell-Free Nucleic AcidsNucleic AcidsRNAbisulfite sequencingcell damagecell-free DNAcell-free RNAclinical severitycoronavirus disease 2019disease biomarkersDNA damagehost responseimmune responsemultisystem inflammatory syndrome in childrennucleic acid sequencingpediatricRNA-seqRNA sequencingSARS-CoV-2signaling pathwayssystems biologytissue damagewhole-blood RNA

Identifiers

PMID37279751
PMCPMC10121104
OpenAlexW4366609040

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.