ArticleProceedings of the National Academy of Sciences of the United States of America2023
Regionally distinct progenitor cells in the lower airway give rise to neuroendocrine and multiciliated cells in the developing human lung.
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Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18citing papers in PubMed
8.3field-weighted citation impact, top 2% of its field
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Who cites it
18 citing papers in PubMed, 32 citations in OpenAlex.
- Deep molecular profiling of lung neuroendocrine tumours and supra-carcinoids.Molecular cancer · 2026Article
- Robust generation of distal respiratory airway organoids by an engineered cuboid chip.Journal of nanobiotechnology · 2026Article
- Epithelial remodeling and microbial dysbiosis in the lower respiratory tract of vitamin A-deficient mouse lungs.Scientific reports · 2026Article
- Transcriptional coordination in multicellular lineage differentiation during lung organogenesis: deciphering the role of epithelial cells as a microenvironmental regulatory hub.Frontiers in cell and developmental biology · 2026Review
- Novel concepts of cell-of origin in neuroendocrine neoplasms.Virchows Archiv : an international journal of pathology · 2026Review
- Hypoxia promotes airway differentiation in the human lung epithelium.Cell stem cell · 2025Article
- Clinical Interventions and Inflammatory Signaling Shape the Transcriptional and Cellular Architecture of the Early Postnatal Lung.bioRxiv : the preprint server for biology · 2025Article
- Gene-ius at Work: Decoding Cell States through Expression.American journal of respiratory cell and molecular biology · 2025Article
- Respiratory microphysiological system in respiratory research: recent advances and future prospects.Respiratory research · 2025Review
- Comprehensive characterization of human alveolar epithelial cells cultured for 28 days at the air-liquid interface.Scientific reports · 2025Article
- An integrated transcriptomic cell atlas of human endoderm-derived organoids.Nature genetics · 2025Article
- SomaticiScience · 2025Article
- Physiological Modeling of the Vascularized Human Lung Organoid.American journal of respiratory cell and molecular biology · 2025Article
- Early human fetal lung atlas reveals the temporal dynamics of epithelial cell plasticity.Nature communications · 2024Article
- Investigating pulmonary neuroendocrine cells in human respiratory diseases with airway models.Disease models & mechanisms · 2024Review
- Lung repair and regeneration: Advanced models and insights into human disease.Cell stem cell · 2024Review
- Alveolar type I cells can give rise to KRAS-induced lung adenocarcinoma.Cell reports · 2023Article
- Opposing roles for TGFβ- and BMP-signaling during nascent alveolar differentiation in the developing human lung.NPJ Regenerative medicine · 2023Article
Corrections and comments
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Authors and funding
16 authors at 4 institutions in 1 country.
Ansley S ConcholaGraduate Program in Cellular and Molecular Biology, University of Michigan Medical School, Ann Arbor, MI 48109.ORCID 0000-0002-2385-6712
Tristan FrumDepartment of Internal Medicine, Division of Gastroenterology and Hepatology, University of Michigan Medical School, Ann Arbor, MI 48109.ORCID 0000-0003-3452-8762
Zhiwei XiaoDepartment of Internal Medicine, Division of Gastroenterology and Hepatology, University of Michigan Medical School, Ann Arbor, MI 48109.
Peggy P HsuDepartment of Internal Medicine, Division of Gastroenterology and Hepatology, University of Michigan Medical School, Ann Arbor, MI 48109.
Kamika KaurDepartment of Internal Medicine, Division of Gastroenterology and Hepatology, University of Michigan Medical School, Ann Arbor, MI 48109.
Michael S DowneyDepartment of Internal Medicine, Division of Gastroenterology and Hepatology, University of Michigan Medical School, Ann Arbor, MI 48109.ORCID 0000-0001-9818-5274
Renee F C HeinDepartment of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109.ORCID 0000-0002-1614-2420
Alyssa J MillerGraduate Program in Cellular and Molecular Biology, University of Michigan Medical School, Ann Arbor, MI 48109.
Yu-Hwai TsaiDepartment of Internal Medicine, Division of Gastroenterology and Hepatology, University of Michigan Medical School, Ann Arbor, MI 48109.
Angeline WuDepartment of Internal Medicine, Division of Gastroenterology and Hepatology, University of Michigan Medical School, Ann Arbor, MI 48109.
Emily M HollowayDepartment of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109.
Abhinav AnandDepartment of Internal Medicine, Division of Gastroenterology and Hepatology, University of Michigan Medical School, Ann Arbor, MI 48109.
Preetish Kadur Lakshminarasimha MurthyDepartment of Pharmacology and Regenerative Medicine, University of Illinois Chicago, IL 60607.
Ian GlassDepartment of Pediatrics, Genetic Medicine, University of Washington, Seattle, WA 98195.
Purushothama R TataDepartment of Cell Biology, Duke University School of Medicine, Durham, NC 27710.ORCID 0000-0003-4837-0337
Jason R SpenceGraduate Program in Cellular and Molecular Biology, University of Michigan Medical School, Ann Arbor, MI 48109.
University of Michigan · USDuke University · USUniversity of Illinois Chicago · USUniversity of Washington · US
Funding
XenograftP30CA046592 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Alexey I Nesvizhskii · 1988 to 2026
$178.2MMICHIGAN MEDICAL SCIENTIST TRAINING PROGRAMT32GM007863 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI COLLINS, KATHLEEN L. · 1985 to 2024
$38.3MTissue Engineering and RegenerationT32DE007057 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DAVID H. KOHN · 1985 to 2026
$17.3MLABORATORY OF DEVELOPMENTAL BIOLOGYR24HD000836 · NICHD · UNIVERSITY OF WASHINGTON · PI Ian Amos Glass · 1995 to 2026
$16.9MSupplement to a Hox-Wnt-Sox signaling axis regulates lung development, patterning and branchingR01HL119215 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SPENCE, JASON · 2013 to 2021
$4.2MCellular Biotechnology Training Program (CBTP) - Years 31-35T32GM145304 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Guizhi Zhu · 2022 to 2026
$2.6MFunctional interrogation of a novel SCGB3A2+/SFTPB+ cell in the human airwayR01HL166139 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Jason Spence · 2023 to 2026
$2.4MCharacterization of a New Epithelial Cell in the Developing Human LungF30HL156474 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CONCHOLA, ANSLEY CORINNE SEMACK · 2021 to 2023
$137kInvestigating the role of mesenchymal R-Spondin2 during human lung developmentF31HL152531 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CONWAY, RENEE FRANCES · 2020 to 2022
$110kInvestigating organ-specific patterning of the vasculature during human developmentF31HL146162 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HOLLOWAY, EMILY MARIE · 2019 to 2020
$74kMechanisms of basal cell differentiation during murine and human lung developmentF31HL142197 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MILLER, ALYSSA JANE · 2018 to 2019
$57kNCI NIH HHS P30 CA046592NHLBI NIH HHS F30 HL156474NHLBI NIH HHS F31 HL142197NHLBI NIH HHS F31 HL146162NHLBI NIH HHS F31 HL152531NHLBI NIH HHS R01 HL119215NHLBI NIH HHS R01 HL166139NICHD NIH HHS R24 HD000836NIDCR NIH HHS T32 DE007057NIGMS NIH HHS T32 GM007863NIGMS NIH HHS T32 GM145304
Abstract
Using scRNA-seq and microscopy, we describe a cell that is enriched in the lower airways of the developing human lung and identified by the unique coexpression of
Indexed as
Cystic Fibrosis Transmembrane Conductance RegulatorLungCell DifferentiationCell LineageEpithelial CellsHumansOrganoidsStem CellsCystic Fibrosis Transmembrane Conductance Regulatorbasal cellbud tip progenitorlung organoidmulticiliated cellneuroendocrine cell
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.