Evidence map›Paper›PMID 37279269›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2023

Chondroitin 4-

Huiqian Huang, Amélie M Joffrin, Yuan Zhao, Gregory M Miller, Grace C Zhang, Yuki Oka, Linda C Hsieh-Wilson

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
7.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.

  1. Pooled it
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  6. GalNAc-T13 maintains neurite architecture and memory retention via O-GalNAc glycosylation of seizure protein 6.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  7. Article
  8. Article
  9. Critical Periods and Beyond: Dynamic Functions of Perineuronal Nets in Cognition, Development, and Disease.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 2 countries.

Huiqian HuangDivision of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125.ORCID 0000-0002-9989-9532
Amélie M JoffrinDivision of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125.
Yuan ZhaoDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125.
Gregory M MillerDivision of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125.
Grace C ZhangDivision of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125.
Yuki OkaDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125.
Linda C Hsieh-WilsonDivision of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125.ORCID 0000-0001-5661-1714
California Institute of Technology · US

Funding

A chemical approach to elucidating the structure-function relationships of chondronitin sulfate glycosaminoglycansR01GM093627 · NIGMS · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI HSIEH-WILSON, LINDA C · 2010 to 2018
$3.6M
NIGMS NIH HHS R01 GM093627
6 · The paper itself

Abstract

Glycan alterations are associated with aging, neuropsychiatric, and neurodegenerative diseases, although the contributions of specific glycan structures to emotion and cognitive functions remain largely unknown. Here, we used a combination of chemistry and neurobiology to show that 4-

Indexed as

Extracellular MatrixNeurodegenerative DiseasesAnimalsChondroitin SulfatesHippocampusMiceNeuronsChondroitin Sulfateschondroitin sulfate (CS)glycansglycosaminoglycans (GAGs)perineuronal nets (PNNs)social memory

Identifiers

PMID37279269
PMCPMC10268298
OpenAlexW4379536226

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.