Evidence map›Paper›PMID 37279179›Full record

ArticleJournal of veterinary internal medicine

Serum proteome profiles in cats with chronic enteropathies.

Jane Yu, Lara Boland, Melissa Catt, Leah Puk, Nadia Wong, Mark Krockenberger, Peter Bennett, Craig Ruaux, Valerie C Wasinger

Open access · goldAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of veterinary internal medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Plasma proteomic profiling in dogs with pheochromocytoma.Journal of veterinary internal medicine · 2026
    Article
  3. Review
  4. Article
  5. Article
  6. Changes in Serum Proteins in Cats with Obesity: A Proteomic Approach.Animals : an open access journal from MDPI · 2025
    Article
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Jane YuSydney School of Veterinary Science, Faculty of Science, The University of Sydney, Sydney, New South Wales, 2006, Australia.ORCID https://orcid.org/0000-0002-4661-8311
Lara BolandSydney School of Veterinary Science, Faculty of Science, The University of Sydney, Sydney, New South Wales, 2006, Australia.
Melissa CattPaddington Cat Hospital, Paddington, New South Wales, Australia.
Leah PukPaddington Cat Hospital, Paddington, New South Wales, Australia.
Nadia WongMcIvor Road Veterinary Centre, Bendigo, Victoria, Australia.
Mark KrockenbergerSydney School of Veterinary Science, Faculty of Science, The University of Sydney, Sydney, New South Wales, 2006, Australia.
Peter BennettSydney School of Veterinary Science, Faculty of Science, The University of Sydney, Sydney, New South Wales, 2006, Australia.ORCID https://orcid.org/0000-0002-7209-4996
Craig RuauxSydney School of Veterinary Science, Faculty of Science, The University of Sydney, Sydney, New South Wales, 2006, Australia.ORCID https://orcid.org/0000-0001-9443-0682
Valerie C WasingerBioanalytical Mass Spectrometry Facility, Mark Wainwright Analytical Centre, University of New South Wales, Sydney, New South Wales, Australia.
The University of Sydney · AUPaddington Cat Hospital · AUBendigo Health · AUUNSW Sydney · AU

Funding

Betty & Keith Cook Canine Research Fund N2151 B3196
6 · The paper itself

Abstract

backgroundSerum protein biomarkers are used to diagnose, monitor treatment response, and to differentiate various forms of chronic enteropathies (CE) in humans. The utility of liquid biopsy proteomic approaches has not been examined in cats. HYPOTHESIS/

objectivesTo explore the serum proteome in cats to identify markers differentiating healthy cats from cats with CE. ANIMALS: Ten cats with CE with signs of gastrointestinal disease of at least 3 weeks duration, and biopsy-confirmed diagnoses, with or without treatment and 19 healthy cats were included.

methodsCross-sectional, multicenter, exploratory study with cases recruited from 3 veterinary hospitals between May 2019 and November 2020. Serum samples were analyzed and evaluated using mass spectrometry-based proteomic techniques.

resultsTwenty-six proteins were significantly (P < .02, ≥5-fold change in abundance) differentially expressed between cats with CE and controls. Thrombospondin-1 (THBS1) was identified with >50-fold increase in abundance in cats with CE (P < 0.001) compared to healthy cats. CONCLUSIONS AND CLINICAL IMPORTANCE: Damage to the gut lining released marker proteins of chronic inflammation that were detectable in serum samples of cats. This early-stage exploratory study strongly supports THBS1 as a candidate biomarker for chronic inflammatory enteropathy in cats.

Indexed as

Cat DiseasesInflammatory Bowel DiseasesAnimalsBiomarkersCatsCross-Sectional StudiesHumansProteomeProteomicsBiomarkersProteomealimentary small cell lymphomabiomarkerschronic enteropathieslow-grade alimentary lymphomaproteinsproteomics

Identifiers

PMID37279179
PMCPMC10365053
OpenAlexW4379599012

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.