Evidence map›Paper›PMID 37279079›Full record

ArticleJournal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine2023

Associations between obstructive sleep apnea and COVID-19 infection and hospitalization among US adults.

Stuart F Quan, Matthew D Weaver, Mark É Czeisler, Laura K Barger, Lauren A Booker, Mark E Howard, Melinda L Jackson, Rashon Lane, Christine F McDonald, Anna Ridgers and 4 more

Open access · bronzeAbstract read
In one paragraph

Article in Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 26 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 2 countries.

Stuart F QuanDivision of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, Massachusetts.
Matthew D WeaverDivision of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, Massachusetts.
Mark É CzeislerFrancis Weld Peabody Society, Harvard Medical School, Boston, Massachusetts.
Laura K BargerDivision of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, Massachusetts.
Lauren A BookerInstitute for Breathing and Sleep, Austin Health, Heidelberg, Victoria, Australia.
Mark E HowardInstitute for Breathing and Sleep, Austin Health, Heidelberg, Victoria, Australia.
Melinda L JacksonSchool of Psychological Sciences, Turner Institute for Brain and Mental Health, Monash University, Melbourne, Victoria, Australia.
Rashon LaneDivision of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, Massachusetts.
Christine F McDonaldInstitute for Breathing and Sleep, Austin Health, Heidelberg, Victoria, Australia.
Anna RidgersInstitute for Breathing and Sleep, Austin Health, Heidelberg, Victoria, Australia.
Rebecca RobbinsDivision of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, Massachusetts.
Prerna VarmaSchool of Psychological Sciences, Turner Institute for Brain and Mental Health, Monash University, Melbourne, Victoria, Australia.
Shantha M W RajaratnamDivision of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, Massachusetts.
Charles A CzeislerDivision of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, Massachusetts.
Institute for Breathing and Sleep · AUCircadian (United States) · USHarvard University · USMonash University · AUBrigham and Women's Hospital · US

Funding

Impact of lifting work hour restrictions on first-year resident safety, health and well-beingR01OH011773 · OH · BRIGHAM AND WOMEN'S HOSPITAL · PI BARGER, LAURA K. · 2019 to 2022
$2.9M
Improving the Health of EMS professionals through Sleep Health Education and Sleep Disorder ScreeningR56HL151637 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI WEAVER, MATTHEW DAVID · 2020 to 2020
$793k
An mHealth intervention to deliver personalized messages to increase adherence to OSA evaluation and treatment among transportation workersK01HL150339 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI ROBBINS, REBECCA · 2020 to 2024
$708k
NHLBI NIH HHS K01 HL150339NHLBI NIH HHS R56 HL151637NIOSH CDC HHS R01 OH011773
6 · The paper itself

Abstract

STUDY

objectivesMedical comorbidities increase the risk of severe COVID-19 infection. In some studies, obstructive sleep apnea (OSA) has been identified as a comorbid condition that is associated with an increased prevalence of COVID-19 infection and hospitalization, but few have investigated this association in a general population. This study aimed to answer the following research question: In a general population, is OSA associated with increased odds of COVID-19 infection and hospitalization and are these altered with COVID-19 vaccination?

methodsThis was a cross-sectional survey of a diverse sample of 15,057 US adults.

resultsCOVID-19 infection and hospitalization rates in the cohort were 38.9% and 2.9%, respectively. OSA or OSA symptoms were reported in 19.4%. In logistic regression models adjusted for demographic, socioeconomic, and comorbid medical conditions, OSA was positively associated with COVID-19 infection (adjusted odds ratio: 1.58, 95% CI: 1.39-1.79) and COVID-19 hospitalization (adjusted odds ratio: 1.55, 95% CI: 1.17-2.05). In fully adjusted models, boosted vaccination status was protective against both infection and hospitalization. Boosted vaccination status attenuated the association between OSA and COVID-19 related hospitalization but not infection. Participants with untreated or symptomatic OSA were at greater risk for COVID-19 infection; those with untreated but not symptomatic OSA were more likely to be hospitalized.

conclusionsIn a general population sample, OSA is associated with a greater likelihood of having had a COVID-19 infection and a COVID-19 hospitalization with the greatest impact observed among persons experiencing OSA symptoms or who were untreated for their OSA. Boosted vaccination status attenuated the association between OSA and COVID-19-related hospitalization. CITATION: Quan SF, Weaver MD, Czeisler MÉ, et al. Associations between obstructive sleep apnea and COVID-19 infection and hospitalization among U.S. adults.

Indexed as

COVID-19Sleep Apnea, ObstructiveAdultCOVID-19 VaccinesCross-Sectional StudiesHospitalizationHumansCOVID-19 VaccinesCOVID-19epidemiologyhospitalizationinfectionobstructive sleep apnea

Identifiers

PMID37279079
PMCPMC10315594
OpenAlexW4361207760

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.