Evidence map›Paper›PMID 37278914›Full record

ArticleJournal of neurology2023

Association between peripheral adaptive immune markers and disease progression in Parkinson's disease.

Yi Xiao, Qianqian Wei, Ruwei Ou, Tianmi Yang, Qirui Jiang, Yanbing Hou, Lingyu Zhang, Kuncheng Liu, Shichan Wang, Junyu Lin and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Constipation Is Linked to Neuroinflammation in Early Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2026
    Article
  4. Peripheral CD4Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Yi XiaoLaboratory of Neurodegenerative Disorders, Department of Neurology, Rare Disease Center, National Clinical Research Center for Geriatric, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Qianqian WeiLaboratory of Neurodegenerative Disorders, Department of Neurology, Rare Disease Center, National Clinical Research Center for Geriatric, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Ruwei OuLaboratory of Neurodegenerative Disorders, Department of Neurology, Rare Disease Center, National Clinical Research Center for Geriatric, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Tianmi YangLaboratory of Neurodegenerative Disorders, Department of Neurology, Rare Disease Center, National Clinical Research Center for Geriatric, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Qirui JiangLaboratory of Neurodegenerative Disorders, Department of Neurology, Rare Disease Center, National Clinical Research Center for Geriatric, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Yanbing HouLaboratory of Neurodegenerative Disorders, Department of Neurology, Rare Disease Center, National Clinical Research Center for Geriatric, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Lingyu ZhangHealth Management Center, West China Hospital of Sichuan University, Chengdu, China.
Kuncheng LiuLaboratory of Neurodegenerative Disorders, Department of Neurology, Rare Disease Center, National Clinical Research Center for Geriatric, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Shichan WangLaboratory of Neurodegenerative Disorders, Department of Neurology, Rare Disease Center, National Clinical Research Center for Geriatric, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Junyu LinLaboratory of Neurodegenerative Disorders, Department of Neurology, Rare Disease Center, National Clinical Research Center for Geriatric, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Bi ZhaoLaboratory of Neurodegenerative Disorders, Department of Neurology, Rare Disease Center, National Clinical Research Center for Geriatric, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Wei SongLaboratory of Neurodegenerative Disorders, Department of Neurology, Rare Disease Center, National Clinical Research Center for Geriatric, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Xueping ChenLaboratory of Neurodegenerative Disorders, Department of Neurology, Rare Disease Center, National Clinical Research Center for Geriatric, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Ying WuLaboratory of Neurodegenerative Disorders, Department of Neurology, Rare Disease Center, National Clinical Research Center for Geriatric, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Chunyu LiLaboratory of Neurodegenerative Disorders, Department of Neurology, Rare Disease Center, National Clinical Research Center for Geriatric, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Huifang ShangLaboratory of Neurodegenerative Disorders, Department of Neurology, Rare Disease Center, National Clinical Research Center for Geriatric, West China Hospital, Sichuan University, Chengdu, Sichuan, China. hfshang2002@126.com.

Funding

National Key Research and Development Plan 2021YFC2501203Sichuan Province Cadre Health Research Project 2022-115Sichuan Province Science and Technology Support Program 2022ZDZX0023
6 · The paper itself

Abstract

backgroundThe pathogenesis of PD has not been fully elucidated, but recent studies have shown that the adaptive immune system may play a role in the pathology of PD. However, there is a lack of longitudinal studies exploring the relationship between peripheral adaptive immune indicators and the rate of disease progression in PD.

methodsWe included early PD patients with disease duration < 3 years and assessed the severity of clinical symptoms and peripheral adaptive immune system indicators (CD3

resultA total of 152 PD patients were eventually included. The linear mixed model showed no significant association between baseline peripheral blood adaptive immune indicators and baseline MoCA scores or UPDRS part III scores. A higher baseline CD3

conclusionThe subset of peripheral T lymphocytes was related to the rate of cognitive decline in early PD patients, suggesting that the peripheral adaptive immune system may be involved in the process of cognitive decline in early PD.

Indexed as

Cognition DisordersCognitive DysfunctionParkinson DiseaseBiomarkersDisease ProgressionHumansBiomarkersCognitionComplementImmune globulinParkinson’s diseasePeripheral immune systemT lymphocytes

Identifiers

PMID37278914
PMCPMC10243250

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.