Evidence map›Paper›PMID 37278911›Full record

ArticleMolecular diversity2024

Structural insights and cytotoxicity evaluation of benz[e]indole pyrazolyl-substituted amides.

Abdul Qaiyum Ramle, Nadia Nabihah Mohd Yusof Chan, Min Phin Ng, Chun Hoe Tan, Kae Shin Sim, Edward R T Tiekink, Chee Chin Fei

Abstract read
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In one paragraph

Article in Molecular diversity, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Abdul Qaiyum RamleSchool of Chemical Sciences, Universiti Sains Malaysia, 11800, Penang, Malaysia. qaiyum@usm.my.
Nadia Nabihah Mohd Yusof ChanDepartment of Chemistry, Universiti Malaya, 50603, Kuala Lumpur, Malaysia.
Min Phin NgInstitute of Biological Sciences, Faculty of Science, Universiti Malaya, 50603, Kuala Lumpur, Malaysia.
Chun Hoe TanDepartment of Biotechnology, Faculty of Applied Science, Lincoln University College, Selangor, Malaysia.
Kae Shin SimInstitute of Biological Sciences, Faculty of Science, Universiti Malaya, 50603, Kuala Lumpur, Malaysia.
Edward R T TiekinkResearch Centre for Crystalline Materials, School of Medical and Life Sciences, Sunway University, Bandar Sunway, 47500, Selangor Darul Ehsan, Malaysia.
Chee Chin FeiNanotechnology and Catalysis Research Centre, Universiti Malaya, 50603, Kuala Lumpur, Malaysia.

Funding

Sunway University GRTIN-RRO-56-2022Universiti Sains Malaysia 304/PKIMIA/6315738
6 · The paper itself

Abstract

Five new compounds of benz[e]indole pyrazolyl-substituted amides (2a-e) were synthesised in low to good yields via the direct amide-coupling reaction between a pyrazolyl derivative containing a carboxylic acid and several amine substrates. The molecular structures were determined by various spectroscopic methods, such as NMR (

Indexed as

AmidesAntineoplastic AgentsIndolesPyrazolesCell Line, TumorCell SurvivalCrystallography, X-RayHCT116 CellsHumansModels, MolecularMolecular Docking SimulationMolecular StructureStructure-Activity RelationshipAmidesAntineoplastic AgentsIndolesPyrazolesCytotoxicityDFTMinor groove bindingX-ray crystallography

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.