Evidence map›Paper›PMID 37278906›Full record

Observational studyGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2023

Structure-function associations between contrast sensitivity and widefield swept-source optical coherence tomography angiography in diabetic macular edema.

Grace Baldwin, Filippos Vingopoulos, Itika Garg, Jade Y Moon, Rebecca Zeng, Ying Cui, Raviv Katz, Rongrong Le, Edward S Lu, Diane N Sayah and 5 more

Abstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 2 countries.

Grace BaldwinHarvard Retinal Imaging Lab, Boston, MA, USA.ORCID http://orcid.org/0000-0001-9872-6974
Filippos VingopoulosHarvard Retinal Imaging Lab, Boston, MA, USA.ORCID http://orcid.org/0000-0003-3778-5473
Itika GargHarvard Retinal Imaging Lab, Boston, MA, USA.ORCID http://orcid.org/0000-0002-9537-8561
Jade Y MoonHarvard Retinal Imaging Lab, Boston, MA, USA.
Rebecca ZengHarvard Retinal Imaging Lab, Boston, MA, USA.
Ying CuiHarvard Retinal Imaging Lab, Boston, MA, USA.
Raviv KatzHarvard Retinal Imaging Lab, Boston, MA, USA.
Rongrong LeHarvard Retinal Imaging Lab, Boston, MA, USA.ORCID http://orcid.org/0000-0002-5837-4545
Edward S LuHarvard Retinal Imaging Lab, Boston, MA, USA.
Diane N SayahHarvard Retinal Imaging Lab, Boston, MA, USA.ORCID http://orcid.org/0000-0002-3734-403X
Zakariyya HassanHarvard Retinal Imaging Lab, Boston, MA, USA.
Leo A KimRetina Service, Massachusetts Eye and Ear, 243 Charles St, Boston, MA, 02114, USA.ORCID http://orcid.org/0000-0001-9106-6416
Tobias ElzeSchepens Eye Research Institute of Massachusetts Eye and Ear, Boston, MA, USA.ORCID http://orcid.org/0000-0002-2032-0496
Deeba HusainRetina Service, Massachusetts Eye and Ear, 243 Charles St, Boston, MA, 02114, USA.ORCID http://orcid.org/0000-0002-8494-0950
John B MillerHarvard Retinal Imaging Lab, Boston, MA, USA. John_Miller@meei.harvard.edu.ORCID http://orcid.org/0000-0003-0109-9738
Massachusetts Eye and Ear Infirmary · USGuangdong Academy of Medical Sciences · CNWenzhou Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo evaluate the relationship between contrast sensitivity (CS) and widefield swept-source optical coherence tomography angiography (WF SS-OCTA) vascular metrics in diabetic macular edema (DME) was the purpose.

methodsThis prospectively enrolled cross-sectional observational study included 61 eyes of 48 patients that were tested with the quantitative CS function (qCSF) test on the same day as imaging with WF SS-OCTA (PLEX® Elite 9000, Carl Zeiss Meditec) 3 × 3, 6 × 6, and 12 × 12 mm scans. Outcomes included visual acuity (VA) and multiple qCSF metrics. Vascular metrics included vessel density (VD) and vessel skeletonized density (VSD) in the superficial (SCP) and deep capillary plexus (DCP) and whole retina (WR) and foveal avascular zone (FAZ) parameters. Mixed effects multivariable linear regression models controlling for age, lens status, and diabetic retinopathy stage were performed. Standardized beta coefficients were calculated by refitting the standardized data.

resultsSS-OCTA metrics had a significant association with CS and VA. The effect size of OCTA metrics was larger on CS compared to VA. For example, the standardized beta coefficients for VSD and CS at 3 cpd (β

conclusionStructure-function associations in patients with DME leveraging the qCSF device suggest microvascular changes on WF SS-OCTA are associated with larger changes in contrast sensitivity than VA.

Indexed as

Contrast SensitivityDiabetic RetinopathyFluorescein AngiographyMacula LuteaMacular EdemaRetinal VesselsTomography, Optical CoherenceVisual AcuityAgedCross-Sectional StudiesFemaleFollow-Up StudiesFundus OculiHumansMaleMiddle AgedContrast sensitivityDiabetic macular edemaDiabetic retinopathyOCTAOptical coherence tomography

Identifiers

PMID37278906
OpenAlexW4379508929

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.