ArticleThe western journal of emergency medicine2023
Association of Early Serum Phosphate Levels and Mortality in Patients with Sepsis.
Article in The western journal of emergency medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- Prognostic value of serum phosphate levels in sepsis: a systematic review and meta-analysis.PeerJ · 2023Pooled it
- Association Between Serum Phosphorus and 28-Day Mortality in Patients with Bloodstream Infection: Potential Prognostic Implication Beyond Renal Function and Clinical Severity.Pathogens (Basel, Switzerland) · 2026Article
- Association between serum phosphate levels and outcome among critically ill newborns: a retrospective cohort study.Frontiers in pediatrics · 2026Article
- Association between serum phosphate levels and length of hospital stay in infants with neonatal sepsis: a retrospective cohort study.BMC pediatrics · 2025Observational
- The sicker the patient, the higher the mortality.Critical care (London, England) · 2025Article
- Article
- Change trends in serum phosphate levels predict in-hospital mortality in critically ill septic patients.Scientific reports · 2025Article
- Effect of changes trajectory of serum phosphate levels on the 28-day mortality risk in patients with sepsis: a retrospective cohort study from the MIMIC-IV database.BMC infectious diseases · 2025Article
- The U-shaped association between initial serum phosphate level and mortality of traumatic brain injury patients.Frontiers in neurology · 2025Article
- Effect of early serum phosphate disorder on in-hospital and 28-day mortality in sepsis patients: a retrospective study based on MIMIC-IV database.BMC medical informatics and decision making · 2024Article
- Hyperphosphatemia in Chronic Kidney Disease: The Search for New Treatment Paradigms and the Role of Tenapanor.International journal of nephrology and renovascular disease · 2024Review
- Exploring the association between serum phosphate levels and mortality in patients hospitalized with infectious diseases: a nationwide study.Frontiers in medicine · 2024Article
- Serum phosphate levels and the development of sepsis associated acute kidney injury: evidence from two independent databases.Frontiers in medicine · 2024Article
Corrections and comments
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Authors and funding
10 authors at 6 institutions in 1 country.
Funding
Abstract
backgroundMetabolic derangements in sepsis influence phosphate levels, which may predict mortality outcomes. We investigated the association between initial phosphate levels and 28-day mortality in patients with sepsis.
methodsWe conducted a retrospective analysis of patients with sepsis. Initial (first 24 hours) phosphate levels were divided into phosphate quartile groups for comparisons. We used repeated-measures mixed-models to assess differences in 28-day mortality across the phosphate groups, adjusting for other predictors identified by the Least Absolute Shrinkage and Selection Operator variable selection technique.
resultsA total of 1,855 patients were included with 13% overall 28-day mortality (n=237). The highest phosphate quartile (>4.0 milligrams per deciliter [mg/dL]) had a higher mortality rate (28%) than the three lower quartiles (P<0.001). After adjustment (age, organ failure, vasopressor administration, liver disease), the highest initial phosphate was associated with increased odds of 28-day mortality. Patients in the highest phosphate quartile had 2.4 times higher odds of death than the lowest (≤2.6 mg/dL) quartile (P<0.01), 2.6 times higher than the second (2.6-3.2 mg/dL) quartile (P<0.01), and 2.0 times higher than the third (3.2-4.0 mg/dL) quartile (P=0.04).
conclusionSeptic patients with the highest phosphate levels had increased odds of mortality. Hyperphosphatemia may be an early indicator of disease severity and risk of adverse outcomes from sepsis.
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