Evidence map›Paper›PMID 37278511›Full record

ArticleAnalytical chemistry2023

Integration of NMR Spectroscopy in an Analytical Workflow to Evaluate the Effects of Oxidative Stress on Abituzumab: Beyond the Fingerprint of mAbs.

Linda Cerofolini, Enrico Ravera, Christian Fischer, Andrea Trovato, Francesca Sacco, Wolf Palinsky, Gabriella Angiuoni, Marco Fragai, Fabio Baroni

Abstract read
In one paragraph

Article in Analytical chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Linda CerofoliniMagnetic Resonance Centre (CERM), University of Florence, Via L. Sacconi 6, 50019 Sesto Fiorentino, Italy.
Enrico RaveraMagnetic Resonance Centre (CERM), University of Florence, Via L. Sacconi 6, 50019 Sesto Fiorentino, Italy.ORCID 0000-0001-7708-9208
Christian FischerBruker BioSpin GmbH, Rudolf-Planck-Str. 23, 76275 Ettlingen, Germany.
Andrea TrovatoAnalytical Development Biotech Department, Merck Serono S.p.a, an affiliate of Merck KGaA, Darmstadt, Germany, Via Luigi Einaudi 11, 00012 Guidonia, (RM), Italy.
Francesca SaccoMagnetic Resonance Centre (CERM), University of Florence, Via L. Sacconi 6, 50019 Sesto Fiorentino, Italy.
Wolf PalinskyBiotech Development Programme, Merck Biopharma, an affiliate of Merck KgaA, Darmstadt, Germany, Zone Industrielle de l'Ouriettaz, 1170 Aubonne, Switzerland.
Gabriella AngiuoniAnalytical Development Biotech Department, Merck Serono S.p.a, an affiliate of Merck KGaA, Darmstadt, Germany, Via Luigi Einaudi 11, 00012 Guidonia, (RM), Italy.
Marco FragaiMagnetic Resonance Centre (CERM), University of Florence, Via L. Sacconi 6, 50019 Sesto Fiorentino, Italy.ORCID 0000-0002-8440-1690
Fabio BaroniAnalytical Development Biotech Department, Merck Serono S.p.a, an affiliate of Merck KGaA, Darmstadt, Germany, Via Luigi Einaudi 11, 00012 Guidonia, (RM), Italy.ORCID 0000-0002-8667-3251

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The assessment of the higher-order structure (HOS) by NMR is a powerful methodology to characterize the structural features of biologics. Forced oxidative stress studies are used to investigate the stability profile, to develop pharmaceutical formulations and analytical methods. Here, the effects of forced oxidative stress by H

Indexed as

Antibodies, MonoclonalHydrogen PeroxideAntibodies, Monoclonal, HumanizedMagnetic Resonance SpectroscopyWorkflowAbituzumabAntibodies, MonoclonalAntibodies, Monoclonal, HumanizedHydrogen Peroxide

Identifiers

PMID37278511
PMCPMC10285717

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.