Evidence map›Paper›PMID 37278194›Full record

ArticleLab on a chip2023

Mitigating neutrophil trafficking and cardiotoxicity with DS-IkL in a microphysiological system of a cytokine storm.

Venktesh S Shirure, Sergey Yechikov, Bhupinder S Shergill, Tima Dehghani, Anton V Block, Harkanwalpreet Sodhi, Alyssa Panitch, Steven C George

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Lab on a chip, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Leveraging Microphysiological Systems to Facilitate Neutrophil-Based Cancer Immunotherapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  2. Article
  3. Vascular microphysiological systems.Current opinion in hematology · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Venktesh S ShirureDepartment of Biomedical Engineering, University of California, Davis, 451 E. Health Sciences Drive, Room 2315, Davis, CA 95616, USA. scgeorge@ucdavis.edu.ORCID 0000-0002-4430-2612
Sergey YechikovDepartment of Biomedical Engineering, University of California, Davis, 451 E. Health Sciences Drive, Room 2315, Davis, CA 95616, USA. scgeorge@ucdavis.edu.
Bhupinder S ShergillDepartment of Biomedical Engineering, University of California, Davis, 451 E. Health Sciences Drive, Room 2315, Davis, CA 95616, USA. scgeorge@ucdavis.edu.
Tima DehghaniDepartment of Biomedical Engineering, University of California, Davis, 451 E. Health Sciences Drive, Room 2315, Davis, CA 95616, USA. scgeorge@ucdavis.edu.
Anton V BlockDepartment of Biomedical Engineering, University of California, Davis, 451 E. Health Sciences Drive, Room 2315, Davis, CA 95616, USA. scgeorge@ucdavis.edu.ORCID 0000-0003-0862-3627
Harkanwalpreet SodhiDepartment of Biomedical Engineering, University of California, Davis, 451 E. Health Sciences Drive, Room 2315, Davis, CA 95616, USA. scgeorge@ucdavis.edu.
Alyssa PanitchDepartment of Biomedical Engineering, University of California, Davis, 451 E. Health Sciences Drive, Room 2315, Davis, CA 95616, USA. scgeorge@ucdavis.edu.
Steven C GeorgeDepartment of Biomedical Engineering, University of California, Davis, 451 E. Health Sciences Drive, Room 2315, Davis, CA 95616, USA. scgeorge@ucdavis.edu.
University of California, Davis · US

Funding

A 3D IN VITRO DISEASE MODEL OF ATRIAL CONDUCTIONUH3HL141800 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CURIEL, DAVID TERRY, GEORGE, STEVEN CARL · 2019 to 2021
$4.0M
A 3D IN VITRO DISEASE MODEL OF ATRIAL CONDUCTIONUG3HL141800 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CURIEL, DAVID TERRY, GEORGE, STEVEN CARL · 2017 to 2018
$2.6M
NHLBI NIH HHS UG3 HL141800NHLBI NIH HHS UH3 HL141800
6 · The paper itself

Abstract

A feature of severe COVID-19 is the onset of an acute and intense systemic inflammatory response referred to as the "cytokine storm". The cytokine storm is characterized by high serum levels of inflammatory cytokines and the subsequent transport of inflammatory cells to damaging levels in vital organs (

Indexed as

COVID-19NeutrophilsAnimalsCardiotoxicityCytokinesEndothelial CellsMiceMicrophysiological SystemsCytokines

Identifiers

PMID37278194
PMCPMC10330849
OpenAlexW4378877748

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.