ArticleBrain and behavior2023
Enhanced functional connectome of cerebellum in chronic insomnia patients.
Article in Brain and behavior, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 10 citations in OpenAlex.
- The Cerebellar Connectome.Cerebellum (London, England) · 2026Article
- Subtyping insomnia disorder with a population graph attention autoencoder: revealing two distinct biotypes.Frontiers in neuroscience · 2026Article
- Abnormal functional activity in the cerebellar crus can distinguish patients with migraine with comorbid insomnia.Frontiers in neuroscience · 2026Article
- Research on the effect of TMS on insomnia patients: EEG changes and prognostic modeling.Frontiers in neuroscience · 2025Article
- Static and temporal dynamic alterations of local functional connectivity in chronic insomnia.Brain imaging and behavior · 2024Article
- Cerebellum in Alzheimer's disease and other neurodegenerative diseases: an emerging research frontier.MedComm · 2024Review
- Enhanced functional connectome of cerebellum in chronic insomnia patients.Brain and behavior · 2023Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFunctional abnormalities of the cerebellum have been found to be closely associated with chronic insomnia (CI). However, whether there are abnormalities in the topology of the functional connectome of the cerebellum in these patients is still unknown. This study aimed to investigate topological abnormalities of the cerebellar functional connectome in individuals with CI. MATERIALS AND
methodsWe used resting-state functional magnetic resonance imaging (rs-fMRI) and graph-theoretic analysis to construct a functional connectivity matrix and extract topological property features of the cerebellar functional connectome in patients with CI. We examined global and nodal topological property changes in the cerebellar functional connectome in 102 patients with CI (CI group) and 101 healthy participants without insomnia symptoms (HC group) to determine the differences between groups. Correlations between the topological properties of the cerebellar functional connectome and clinical assessments were calculated to confirm the differences between groups.
resultsThe cerebellar functional connectome of both CI and HC patients exhibited small-world properties. The CI group showed higher standardized clustering coefficients at the global properties and higher betweenness centrality in the cerebellar Crus II vermis region at the nodal properties compared with participants in the HC group. However, the topological properties of cerebellar functional connectome abnormalities in the CI group were not significantly different from those in clinical assessments.
conclusionOur findings suggest that the abnormal global and nodal topological properties of the cerebellar functional connectome are associated with CI and could serve as an important biomarker for CI.
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