Evidence map›Paper›PMID 37278122›Full record

ArticleESC heart failure2023

Performance of a multisensor implantable defibrillator algorithm for heart failure monitoring related to co-morbidities.

Vincenzo Ezio Santobuono, Stefano Favale, Antonio D'Onofrio, Michele Manzo, Leonardo Calò, Matteo Bertini, Gianluca Savarese, Luca Santini, Antonio Dello Russo, Carlo Lavalle and 10 more

Open access · goldAbstract read
In one paragraph

Article in ESC heart failure, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 2 pooled it
3.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 14 citations in OpenAlex.

  1. Pooled it
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  13. Performance of a multi-sensor implantable defibrillator algorithm for heart failure monitoring in the presence of atrial fibrillation.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2023
    Observational
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 16 institutions in 2 countries.

Vincenzo Ezio SantobuonoInterdisciplinary Department of Medicine, Cardiology Unit Polyclinic of Bari, University of Bari 'Aldo Moro', Bari, Italy.
Stefano FavaleInterdisciplinary Department of Medicine, Cardiology Unit Polyclinic of Bari, University of Bari 'Aldo Moro', Bari, Italy.
Antonio D'OnofrioUnità Operativa di Elettrofisiologia, Studio e Terapia delle Aritmie', Monaldi Hospital, Naples, Italy.
Michele ManzoOO.RR. San Giovanni di Dio Ruggi d'Aragona, Salerno, Italy.
Leonardo CalòPoliclinico Casilino, Rome, Italy.
Matteo BertiniUniversity of Ferrara, S. Anna University Hospital, Ferrara, Italy.
Gianluca SavareseS. Giovanni Battista Hospital, Foligno, Italy.
Luca Santini'Giovan Battista Grassi' Hospital, Rome, Italy.
Antonio Dello RussoUniversità Politecnica delle Marche, 'Ospedali Riuniti', Ancona, Italy.
Carlo LavallePoliclinico Umberto I, Rome, Italy.
Miguel ViscusiS. Anna e S. Sebastiano Hospital, Caserta, Italy.
Claudia Amellone'Maria Vittoria' Hospital, Turin, Italy.
Raimondo CalvaneseOspedale del Mare, ASL NA1, Naples, Italy.
Giuseppe ArenaOspedale Civile Apuane, Massa, Italy.
Antonio Pangallo'Bianchi-Melacrino-Morelli' Hospital, Reggio Calabria, Italy.
Antonio RapacciuoloPoliclinico Federico II, Naples, Italy.
Daniele PorcelliS. Pietro Fatebenefratelli Hospital, Rome, Italy.
Monica CampariBoston Scientific Italia, Milan, Italy.
Sergio ValsecchiBoston Scientific Italia, Milan, Italy.
Andrea Igoren GuaricciInterdisciplinary Department of Medicine, Cardiology Unit Polyclinic of Bari, University of Bari 'Aldo Moro', Bari, Italy.
University of Bari Aldo Moro · ITAzienda Ospedaliero Universitaria San Giovanni Battista · ITBoston Scientific (United States) · USAzienda ospedaliera "Bianchi-Melacrino-Morelli" · ITFatebenefratelli Hospital · ITFederico II University Hospital · ITMarche Polytechnic University · ITOspedale Civile di Giaveno · ITOspedale D. Cotugno · ITOspedale Maria Vittoria · ITOspedale Monaldi · ITOspedale Sant'Anna · ITOspedali Riuniti San Giovanni di Dio e Ruggi d'Aragona · ITPoliclinico Casilino · ITPoliclinico Umberto I · ITUniversity of Ferrara · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsThe HeartLogic algorithm combines multiple implantable defibrillator (ICD) sensor data and has proved to be a sensitive and timely predictor of impending heart failure (HF) decompensation in cardiac resynchronization therapy (CRT-D) patients. We evaluated the performance of this algorithm in non-CRT ICD patients and in the presence of co-morbidities. METHODS AND

resultsThe HeartLogic feature was activated in 568 ICD patients (410 with CRT-D) from 26 centres. The median follow-up was 26 months [25th-75th percentile: 16-37]. During follow-up, 97 hospitalizations were reported (53 cardiovascular) and 55 patients died. We recorded 1200 HeartLogic alerts in 370 patients. Overall, the time IN the alert state was 13% of the total observation period. The rate of cardiovascular hospitalizations or death was 0.48/patient-year (95% CI: 0.37-0.60) with the HeartLogic IN the alert state and 0.04/patient-year (95% CI: 0.03-0.05) OUT of the alert state, with an incidence rate ratio of 13.35 (95% CI: 8.83-20.51, P < 0.001). Among patient characteristics, atrial fibrillation (AF) on implantation (HR: 1.62, 95% CI: 1.27-2.07, P < 0.001) and chronic kidney disease (CKD) (HR: 1.53, 95% CI: 1.21-1.93, P < 0.001) independently predicted alerts. HeartLogic alerts were not associated with CRT-D versus ICD implantation (HR: 1.03, 95% CI: 0.82-1.30, P = 0.775). Comparisons of the clinical event rates in the IN alert state with those in the OUT of alert state yielded incidence rate ratios ranging from 9.72 to 14.54 (all P < 0.001) in all groups of patients stratified by: CRT-D/ICD, AF/non-AF, and CKD/non-CKD. After multivariate correction, the occurrence of alerts was associated with cardiovascular hospitalization or death (HR: 1.92, 95% CI: 1.05-3.51, P = 0.036).

conclusionsThe burden of HeartLogic alerts was similar between CRT-D and ICD patients, while patients with AF and CKD seemed more exposed to alerts. Nonetheless, the ability of the HeartLogic algorithm to identify periods of significantly increased risk of clinical events was confirmed, regardless of the type of device and the presence of AF or CKD.

Indexed as

Atrial FibrillationCardiac Resynchronization TherapyDefibrillators, ImplantableHeart FailureAlgorithmsHumansMorbidityAtrial fibrillationChronic kidney diseaseCRTHeart failureICDRisk stratification

Identifiers

PMID37278122
PMCPMC10375157
OpenAlexW4379507869

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.