ArticleAging cell2023
Mendelian randomization supports causality between overweight status and accelerated aging.
Article in Aging cell, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- [Association between 473 gut microbiota and Alzheimer's disease: a Mendelian randomization mediation analysis of 233 circulating metabolites].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2026Article
- Role of IFIT1 and IFIT3 in systemic lupus erythematosus: modeling a diagnosis and exploring immune regulation.Clinical and experimental medicine · 2026Article
- Genetically Proxied Biological Aging and Risk of Hypertrophic Scar/Keloid-Coded Phenotypes: An Exploratory Two-Sample Mendelian Randomization Study.Clinical, cosmetic and investigational dermatology · 2026Article
- A systematic exploration of gut microbiota-driven blood metabolites in sepsis: an integrated bioinformatics and genetic association study.Frontiers in genetics · 2026Article
- Exploring the Causal Relationship and Potential Mediating Mechanisms Between Obesity and Facial Aging: A Two-Sample, Multivariable and Mediation Mendelian Randomization Study.Clinical, cosmetic and investigational dermatology · 2026Article
- Dietary and Pharmacological Modulation of Aging-Related Metabolic Pathways: Molecular Insights, Clinical Evidence, and a Translational Model.International journal of molecular sciences · 2025Review
- Obesity impact on leukocyte telomere shortening and immune aging assessed by Mendelian randomization and transcriptomics analysis.Scientific reports · 2025Article
- Association between depression and asthma: insight from observational and genetic evidence.BMC psychiatry · 2025Observational
- A Longitudinal Study of the Bidirectional Temporal Dynamics Between Body Mass Index and Biological Aging.Journal of cachexia, sarcopenia and muscle · 2025Article
- Biological Age Acceleration Associated with the Progression Trajectory of Cardio-Renal-Metabolic Multimorbidity: A Prospective Cohort Study.Nutrients · 2025Article
- Association Between Serum Apolipoprotein B and Bone Mineral Density and the Effects of Cardiovascular Disease Mediation: Results From the NHANES 2011-2016 and a Mendelian Randomization Study.Reviews in cardiovascular medicine · 2025Article
- Causal association between dietary factors and telomere length revealed by mendelian randomization.Scientific reports · 2025Article
- Article
- Bidirectional genetic links between chronic obstructive pulmonary disease and frailty: Genome-wide association study insights.PloS one · 2025Article
- Effects of Diabetes Mellitus and Glycemic Traits on COPD and Pulmonary Function Traits: Insights From Mendelian Randomization and NHANES.International journal of chronic obstructive pulmonary disease · 2025Article
- The translation initiation factor eIF2α regulates lipid homeostasis and metabolic aging.Aging cell · 2025Article
- Association between triglyceride-glucose index and phenotypic age acceleration: a cross-sectional study based on NHANES database.Frontiers in physiology · 2025Article
- Causal Association Between Obstructive Sleep Apnea and Migraine: A Bidirectional Mendelian Randomization Study.Nature and science of sleep · 2025Article
- Associations of Body Mass Index and Percent Body Fat with Osteoporosis, Sarcopenia, and Osteosarcopenia: A Retrospective Study Based on Postmenopausal Women in China.Healthcare (Basel, Switzerland) · 2024Article
- Hyperthyroidism increases the risk of osteoarthritis in individuals aged 60-80 years.Scientific reports · 2024Article
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Authors and funding
3 authors.
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Abstract
It is reported that overweight may lead to accelerated aging. However, there is still a lack of evidence on the causal effect of overweight and aging. We collected genetic variants associated with overweight, age proxy indicators (telomere length, frailty index and facial aging), etc., from genome-wide association studies datasets. Then we performed MR analyses to explore associations between overweight and age proxy indicators. MR analyses were primarily conducted using the inverse variance weighted method, followed by various sensitivity and validation analyses. MR analyses indicated that there were significant associations of overweight on telomere length, frailty index, and facial aging (β = -0.018, 95% CI = -0.033 to -0.003, p = 0.0162; β = 0.055, 95% CI = 0.030-0.079, p < 0.0001; β = 0.029, 95% CI = 0.013-0.046, p = 0.0005 respectively). Overweight also had a significant negative causality with longevity expectancy (90th survival percentile, β = -0.220, 95% CI = -0.323 to -0.118, p < 0.0001; 99th survival percentile, β = -0.389, 95% CI = -0.652 to -0.126, p = 0.0038). Moreover, the findings tend to favor causal links between body fat mass/body fat percentage on aging proxy indicators, but not body fat-free mass. This study provides evidence of the causality between overweight and accelerated aging (telomere length decreased, frailty index increased, facial aging increased) and lower longevity expectancy. Accordingly, the potential significance of weight control and treatment of overweight in combating accelerated aging need to be emphasized.
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