ArticleNature communications2023
Wide-spread brain activation and reduced CSF flow during avian REM sleep.
Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 36 citations in OpenAlex.
- T. rex cognition was T. rex-like-A critical outlook on diverging views of the neurocognitive evolution in dinosaurs.Anatomical record (Hoboken, N.J. : 2007) · 2026Review
- A soft wearable near-infrared spectroscopy system for detecting brain water dynamics linked to glymphatic activity during sleep.Science advances · 2026Article
- REM-sleep twitching in adults and the maintenance of specialized sensorimotor systems.Current biology : CB · 2026Review
- Article
- The circadian clock regulates scavenging of fluid-borne substrates by brain border-associated macrophages.bioRxiv : the preprint server for biology · 2025Article
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- Imaging cellular activity simultaneously across all organs of a vertebrate reveals body-wide circuits.bioRxiv : the preprint server for biology · 2025Article
- Exploring Neural Dynamics in the Auditory Telencephalon of Crows Using Functional Ultrasound Imaging.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Revolutionizing Sleep Science: A Narrative Review of the Historical Origins and Current Applications of Sleep Neuroimaging.Nature and science of sleep · 2025Review
- Increased intra-thalamic and thalamo-cortical functional connections during human REM sleep: Insights from a two-night EEG-fMRI study.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Dinosaur palaeoneurology: an evolving science.Biology letters · 2024Review
- Attentional failures after sleep deprivation represent moments of cerebrospinal fluid flow.bioRxiv : the preprint server for biology · 2024Article
- A short natural history of mental time travels: a journey still travelled?Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Article
- Functional MRI of imprinting memory in awake newborn domestic chicks.Communications biology · 2024Article
- The new science of sleep: From cells to large-scale societies.PLoS biology · 2024Article
- Why birds are smart.Trends in cognitive sciences · 2024Review
- Quantitative functional imaging of the pigeon brain: implications for the evolution of avian powered flight.Proceedings. Biological sciences · 2024Article
- Wide-spread brain activation and reduced CSF flow during avian REM sleep.Nature communications · 2023Article
- Editorial: Awake functional imaging of small animals.Frontiers in neuroscience · 2023Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mammalian sleep has been implicated in maintaining a healthy extracellular environment in the brain. During wakefulness, neuronal activity leads to the accumulation of toxic proteins, which the glymphatic system is thought to clear by flushing cerebral spinal fluid (CSF) through the brain. In mice, this process occurs during non-rapid eye movement (NREM) sleep. In humans, ventricular CSF flow has also been shown to increase during NREM sleep, as visualized using functional magnetic resonance imaging (fMRI). The link between sleep and CSF flow has not been studied in birds before. Using fMRI of naturally sleeping pigeons, we show that REM sleep, a paradoxical state with wake-like brain activity, is accompanied by the activation of brain regions involved in processing visual information, including optic flow during flight. We further demonstrate that ventricular CSF flow increases during NREM sleep, relative to wakefulness, but drops sharply during REM sleep. Consequently, functions linked to brain activation during REM sleep might come at the expense of waste clearance during NREM sleep.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.