Evidence map›Paper›PMID 37276802›Full record

ArticleEpilepsy & behavior : E&B2023

Evaluating salvage electroconvulsive therapy for the treatment of prolonged super refractory status epilepticus: A case series.

Matthew R Woodward, Seshagiri Doddi, Christopher Marano, William Regenold, Jennifer Pritchard, Stephanie Chen, Megan Margiotta, Wan-Tsu W Chang, Ayham Alkhachroum, Nicholas A Morris

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Epilepsy & behavior : E&B, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
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  4. Article
  5. Status epilepticus in the ICU.Intensive care medicine · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Matthew R WoodwardDepartments of Neurology, University of Maryland School of Medicine, Baltimore, MD, USA; Program in Trauma, R Adams Cowley Shock Trauma Center, Baltimore, MD, USA. Electronic address: mrwoodward@som.umaryland.edu.
Seshagiri DoddiDepartments of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA.
Christopher MaranoDepartments of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA.
William RegenoldNoninvasive Neuromodulation Unit, Experimental Therapeutics & Pathophysiology Branch, National Institute of Mental Health, Bethesda, MD, USA.
Jennifer PritchardDepartments of Neurology, University of Maryland School of Medicine, Baltimore, MD, USA.
Stephanie ChenDepartments of Neurology, University of Maryland School of Medicine, Baltimore, MD, USA.
Megan MargiottaDepartments of Neurology, University of Maryland School of Medicine, Baltimore, MD, USA.
Wan-Tsu W ChangDepartments of Neurology, University of Maryland School of Medicine, Baltimore, MD, USA; Departments of Emergency Medicine, University of Maryland School of Medicine, Baltimore, MD, USA; Program in Trauma, R Adams Cowley Shock Trauma Center, Baltimore, MD, USA.
Ayham AlkhachroumDepartment of Neurology, University of Miami, Miami, FL, USA.
Nicholas A MorrisDepartments of Neurology, University of Maryland School of Medicine, Baltimore, MD, USA; Program in Trauma, R Adams Cowley Shock Trauma Center, Baltimore, MD, USA.
University of Maryland, Baltimore · USNational Institute of Mental Health · USUniversity of Miami · US

Funding

Non-invasive Neuromodulation Unit (NNU)ZIAMH002955 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI ZARATE, CARLOS · 2016 to 2025
$40.3M
Miami Clinical and Translational Science InstituteUL1TR002736 · NCATS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI CARRASQUILLO, OLVEEN, KOBETZ, ERIN N · 2018 to 2022
$23.2M
NRSA Training CoreTL1TR003100 · NCATS · JOHNS HOPKINS UNIVERSITY · PI SAHA, SOMNATH · 2019 to 2023
$4.5M
MUSICA - MUsic and Speech Induced Cerebral ActivationK23NS126577 · NINDS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Ayham Alkhachroum · 2022 to 2026
$910k
COVERT– COvert Volitional Eye Response TestR21NS128326 · NINDS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI ALKHACHROUM, AYHAM, CLAASSEN, JAN · 2022 to 2023
$428k
Intramural NIH HHS ZIA MH002955NCATS NIH HHS TL1 TR003100NCATS NIH HHS UL1 TR002736NINDS NIH HHS K23 NS126577NINDS NIH HHS R21 NS128326
6 · The paper itself

Abstract

BACKGROUND AND

objectivesClinicians have treated super refractory status epilepticus (SRSE) with electroconvulsive therapy (ECT); however, data supporting the practice are scant and lack rigorous evaluation of continuous electroencephalogram (cEEG) changes related to therapy. This study aims to describe a series of patients with SRSE treated at our institution with ECT and characterize cEEG changes using a blinded review process.

methodsWe performed a single-center retrospective study of consecutive patients admitted for SRSE and treated with ECT from January 2014 to December 2022. Our primary outcome was the resolution of SRSE. Secondary outcomes included changes in ictal-interictal EEG patterns, anesthetic burden, treatment-associated adverse events, and changes in clinical examination. cEEG was reviewed pre- and post-ECT by blinded epileptologists.

resultsTen patients underwent treatment with ECT across 11 admissions (8 female, median age 57 years). At the time of ECT initiation, nine patients had ongoing SRSE while two had highly ictal patterns and persistent encephalopathy following anesthetic wean, consistent with late-stage SRSE. Super-refractory status epilepticus resolution occurred with a median time to cessation of 4 days (interquartile range [IQR]: 3-9 days) following ECT initiation. Background continuity improved in five patients and periodic discharge frequency decreased in six. There was a decrease in anesthetic use following the completion of ECT and an improvement in neurological exams. There were no associated adverse events. DISCUSSION: In our cohort, ECT was associated with improvement of ictal-interictal patterns on EEG, and resolution of SRSE, and was not associated with serious adverse events. Further controlled studies are needed.

Indexed as

Drug Resistant EpilepsyElectroconvulsive TherapyStatus EpilepticusFemaleHumansMiddle AgedResearch DesignRetrospective StudiesAnti-seizure therapyElectroconvulsive therapyElectroencephalographyStatus epilepticusSuper refractory status epilepticus

Identifiers

PMID37276802
PMCPMC10330823
OpenAlexW4379191966

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.