Evidence map›Paper›PMID 37276438›Full record

ArticleJournal of natural products2023

Appraisal of Fungus-Derived Xanthoquinodins as Broad-Spectrum Anti-Infectives Targeting Phylogenetically Diverse Human Pathogens.

Jin Woo Lee, Jennifer E Collins, Matthew A Hulverson, Laarni Kendra T Aguila, Caroline M Kim, Karen L Wendt, Debopam Chakrabarti, Kayode K Ojo, Gwendolyn E Wood, Wesley C Van Voorhis and 1 more

Abstract read
In one paragraph

Article in Journal of natural products, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Fungal-derived methyldeoxaphomins targetProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jin Woo LeeNatural Products Discovery Group, Institute for Natural Products Applications and Research Technologies, Department of Chemistry and Biochemistry, Stephenson Life Sciences Research Center, University of Oklahoma, Norman, Oklahoma 73019, United States.
Jennifer E CollinsDivision of Molecular Microbiology, Burnett School of Biomedical Sciences, University of Central Florida, Orlando, Florida 32826, United States.ORCID 0000-0002-1195-4630
Matthew A HulversonCenter for Emerging and Re-emerging Infectious Diseases (CERID), Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, 358061, 750 Republican Street, Seattle, Washington 98109, United States.ORCID 0000-0002-3413-4969
Laarni Kendra T AguilaDivision of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, Washington 98104, United States.
Caroline M KimDivision of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, Washington 98104, United States.
Karen L WendtNatural Products Discovery Group, Institute for Natural Products Applications and Research Technologies, Department of Chemistry and Biochemistry, Stephenson Life Sciences Research Center, University of Oklahoma, Norman, Oklahoma 73019, United States.
Debopam ChakrabartiDivision of Molecular Microbiology, Burnett School of Biomedical Sciences, University of Central Florida, Orlando, Florida 32826, United States.
Kayode K OjoCenter for Emerging and Re-emerging Infectious Diseases (CERID), Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, 358061, 750 Republican Street, Seattle, Washington 98109, United States.
Gwendolyn E WoodDivision of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, Washington 98104, United States.
Wesley C Van VoorhisCenter for Emerging and Re-emerging Infectious Diseases (CERID), Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, 358061, 750 Republican Street, Seattle, Washington 98109, United States.ORCID 0000-0001-6141-2015
Robert H CichewiczNatural Products Discovery Group, Institute for Natural Products Applications and Research Technologies, Department of Chemistry and Biochemistry, Stephenson Life Sciences Research Center, University of Oklahoma, Norman, Oklahoma 73019, United States.ORCID 0000-0003-0744-4117

Funding

Optimization of Lead BKIs for Cryptosporidiosis TherapyR01AI155412 · NIAID · UNIVERSITY OF WASHINGTON · PI VAN VOORHIS, WESLEY C · 2021 to 2025
$4.1M
Novel Antimalarials from FungiR01AI154777 · NIAID · UNIVERSITY OF CENTRAL FLORIDA · PI CHAKRABARTI, DEBOPAM, CICHEWICZ, ROBERT HENRY · 2020 to 2024
$3.8M
Development of Dual Efficacy Therapeutic Against Cryptosporidiosis and GiardiasisR21AI140881 · NIAID · UNIVERSITY OF WASHINGTON · PI OJO, KAYODE K · 2019 to 2020
$477k
Fungal natural products targeting antimicrobial resistant Mycoplasma genitaliumR21AI153863 · NIAID · UNIVERSITY OF OKLAHOMA · PI CICHEWICZ, ROBERT HENRY, WOOD, GWENDOLYN · 2021 to 2022
$441k
Discovery of Novel Antimalarial Compounds from FungiR21AI143052 · NIAID · UNIVERSITY OF CENTRAL FLORIDA · PI CHAKRABARTI, DEBOPAM, CICHEWICZ, ROBERT HENRY · 2019 to 2020
$423k
NIAID NIH HHS R01 AI154777NIAID NIH HHS R01 AI155412NIAID NIH HHS R21 AI140881NIAID NIH HHS R21 AI143052NIAID NIH HHS R21 AI153863
6 · The paper itself

Abstract

Xanthoquinodins make up a distinctive class of xanthone-anthraquinone heterodimers reported as secondary metabolites from several fungal species. Through a collaborative multi-institutional screening program, a fungal extract prepared from a

Indexed as

Anti-Infective AgentsCryptosporidiosisCryptosporidiumMitosporic FungiAnti-Bacterial AgentsHumansMolecular StructureAnti-Bacterial AgentsAnti-Infective Agents

Identifiers

PMID37276438
PMCPMC10797637

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.