Evidence map›Paper›PMID 37276387›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2023

Robust regulation of transcription pausing in

Alexander V Yakhnin, Mikhail Bubunenko, Zachary F Mandell, Lucyna Lubkowska, Sara Husher, Paul Babitzke, Mikhail Kashlev

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. RNAP-seq:bioRxiv : the preprint server for biology · 2026
    Article
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  5. Article
  6. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Alexander V YakhninRNA Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702.ORCID 0000-0002-7313-7054
Mikhail BubunenkoRNA Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702.ORCID 0009-0004-7906-9488
Zachary F MandellDepartment of Biochemistry and Molecular Biology, Center for RNA Molecular Biology, Pennsylvania State University, University Park, PA 16802.
Lucyna LubkowskaRNA Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702.
Sara HusherRNA Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702.
Paul BabitzkeDepartment of Biochemistry and Molecular Biology, Center for RNA Molecular Biology, Pennsylvania State University, University Park, PA 16802.ORCID 0000-0003-2481-1062
Mikhail KashlevRNA Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702.ORCID 0000-0002-1260-6486
National Cancer Institute · USPennsylvania State University · US

Funding

Mechanisms of transcription pausing and fidelity in prokaryotes and eukaryotesZIABC010795 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI KASHLEV, MIKHAIL · 2009 to 2025
$18.1M
Regulation of transcription elongationR01GM098399 · NIGMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI BABITZKE, PAUL L · 2012 to 2024
$3.6M
Mechanisms of transcription fidelity in prokaryotes and eukaryotesZ01BC010795 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI KASHLEV, MIKHAIL · 2007 to 2008
$1.1M
Intramural NIH HHS Z01 BC010795Intramural NIH HHS ZIA BC010795NIGMS NIH HHS R01 GM098399
6 · The paper itself

Abstract

Transcription elongation by multi-subunit RNA polymerases (RNAPs) is regulated by auxiliary factors in all organisms. NusG/Spt5 is the only universally conserved transcription elongation factor shared by all domains of life. NusG is a component of antitermination complexes controlling ribosomal RNA operons, an essential antipausing factor, and a transcription-translation coupling factor in

Indexed as

Escherichia coliEscherichia coli ProteinsDNA-Directed RNA PolymerasesPeptide Elongation FactorsTranscription FactorsTranscription, GeneticDNA-Directed RNA PolymerasesEscherichia coli ProteinsNusG protein, E coliPeptide Elongation FactorsTranscription FactorsbacktrackingNusGRNA polymerase pausingRNET-seqtranslocation

Identifiers

PMID37276387
PMCPMC10268239
OpenAlexW4379467908

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.