ArticleJournal of applied clinical medical physics2023
Influence of air mapping errors on the dosimetric accuracy of prostate CBCT-guided online adaptive radiation therapy.
Article in Journal of applied clinical medical physics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 12 citations in OpenAlex.
- Comparison of deformable image registration algorithms for planning CT and CBCT in prostate cancer patients treated with external beam radiation therapy.Radiological physics and technology · 2026Article
- Effects of air on the dosimetric robustness of treatment plans for prostate cancer in the presence of intrafractional, anatomical changes during online adaptive radiotherapy.Journal of applied clinical medical physics · 2026Article
- Development of nasopharyngeal carcinoma target delineation: from two-dimensional radiotherapy to adaptive precision radiotherapy.Journal of Cancer · 2026Review
- Deep learning-based synthetic-CT-free photon dose calculation in MR-guided radiotherapy: A proof-of-concept study.Medical physics · 2025Article
- Cone Beam Computed Tomography Image-Quality Improvement Using "One-Shot" Super-resolution.Journal of imaging informatics in medicine · 2025Article
- Geometrically focused training and evaluation of organs-at-risk segmentation via deep learning.Medical physics · 2025Article
- Evaluation of model uncertainty in AI-based synthetic CT generation from CBCT for abdominal adaptive radiotherapy.Medical physics · 2025Article
- Article
- Proof of concept of fully automated adaptive workflow for head and neck radiotherapy treatments with a conventional linear accelerator.Frontiers in oncology · 2025Article
- Uncertainty estimation in female pelvic synthetic computed tomography generated from iterative reconstructed cone-beam computed tomography.Physics and imaging in radiation oncology · 2025Article
- Evaluation of the geometric and dosimetric accuracies of deformable image registration of targets and critical organs in prostate CBCT-guided adaptive radiotherapy.Journal of applied clinical medical physics · 2024Article
- MU variability in CBCT-guided online adaptive radiation therapy.Journal of applied clinical medical physics · 2024Article
- Influence of air mapping errors on the dosimetric accuracy of prostate CBCT-guided online adaptive radiation therapy.Journal of applied clinical medical physics · 2023Article
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10 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
purposeCBCT-guided online adaptive radiotherapy (oART) plans presently utilize daily synthetic CTs (sCT) that are automatically generated using deformable registration algorithms. These algorithms may have poor performance at reproducing variable volumes of gas present during treatment. Therefore, we have analyzed the air mapping error between the daily CBCTs and the corresponding sCT and explored its dosimetric effect on oART plan calculation.
methodsAbdominopelvic air volume was contoured on both the daily CBCT images and the corresponding synthetic images for 207 online adaptive pelvic treatments. Air mapping errors were tracked over all fractions. For two case studies representing worst case scenarios, dosimetric effects of air mapping errors were corrected in the sCT images using the daily CBCT air contours, then recalculating dose. Dose volume histogram statistics and 3D gamma passing rates were used to compare the original and air-corrected sCT-based dose calculations.
resultsAll analyzed patients showed observable air pocket contour differences between the sCT and the CBCT images. The largest air volume difference observed in daily CBCT images for a given patient was 276.3 cc, a difference of more than 386% compared to the sCT. For the two case studies, the largest observed change in DVH metrics was a 2.6% reduction in minimum PTV dose, with all other metrics varying by less than 1.5%. 3D gamma passing rates using 1%/1 mm criteria were above 90% when comparing the uncorrected and corrected dose distributions.
conclusionCurrent CBCT-based oART workflow can lead to inaccuracies in the mapping of abdominopelvic air pockets from daily CBCT to the sCT images used for the optimization and calculation of the adaptive plan. Despite the large observed mapping errors, the dosimetric effects of such differences on the accuracy of the adapted plan dose calculation are unlikely to cause differences greater than 3% for prostate treatments.
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