ArticleThe European physical journal. Special topics2020
Folding drives cortical thickness variations.
Article in The European physical journal. Special topics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 23 citations in OpenAlex.
- Mechanisms of transcranial magnetic brain stimulation.Physiological reviews · 2026Review
- Biophysical modeling of anatomically realistic prenatal cortical folding development.Nature communications · 2026Article
- Brain Organoids: Emerging Platforms for Modern Neuroscience.Brain sciences · 2026Review
- How do infant brains fold? Sulcal deepening is linked to development of sulcal span, thickness, curvature, and microstructure.Communications biology · 2026Article
- Sulcal pits as potential markers of early sex-related human brain differences in healthy adults.Biology of sex differences · 2025Article
- Mechanical stress connects cortical folding to fiber organization in the developing brain.Trends in neurosciences · 2025Review
- Fast whole brain relaxometry with Magnetic Resonance Spin TomogrAphy in Time-domain (MR-STAT) at 3 T: a retrospective cohort study.Magma (New York, N.Y.) · 2025Article
- Article
- Quantifying the Timing of Gyral and Sulcal Formation Relative to Growth in the Ferret Cerebral Cortex.Developmental neuroscience · 2025Article
- Causal associations between chronic heart failure and the cerebral cortex: results from Mendelian randomization study and integrated bioinformatics analysis.Frontiers in cardiovascular medicine · 2024Article
- Multi-scale measurement of stiffness in the developing ferret brain.Scientific reports · 2023Article
- Cortical thickness systematically varies with curvature and depth in healthy human brains.Human brain mapping · 2022Article
- Compensating cortical thickness for cortical folding-related variation.Imaging neuroscience (Cambridge, Mass.)Article
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Authors and funding
6 authors at 6 institutions in 3 countries.
Funding
Abstract
The cortical thickness is a characteristic biomarker for a wide variety of neurological disorders. While the structural organization of the cerebral cortex is tightly regulated and evolutionarily preserved, its thickness varies widely between 1.5 and 4.5 mm across the healthy adult human brain. It remains unclear whether these thickness variations are a cause or consequence of cortical development. Recent studies suggest that cortical thickness variations are primarily a result of genetic effects. Previous studies showed that a simple homogeneous bilayered system with a growing layer on an elastic substrate undergoes a unique symmetry breaking into a spatially heterogeneous system with discrete gyri and sulci. Here, we expand on that work to explore the evolution of cortical thickness variations over time to support our finding that cortical pattern formation and thickness variations can be explained - at least in part - by the physical forces that emerge during cortical folding. Strikingly, as growth progresses, the developing gyri universally thicken and the sulci thin, even in the complete absence of regional information. Using magnetic resonance images, we demonstrate that these naturally emerging thickness variations agree with the cortical folding pattern in
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