ReviewStructural heart : the journal of the Heart Team2023
The Natural History of Bicuspid Aortic Valve Disease.
Review in Structural heart : the journal of the Heart Team, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 22 citations in OpenAlex.
- Undiagnosed Thoracic Aortic Aneurysms: Prevalence, Risk Factors, Screening Modalities.Deutsches Arzteblatt international · 2026Review
- Paroxysmal atrioventricular block as an initial presentation of bicuspid aortic valve calcification: a case report.European heart journal. Case reports · 2026Article
- A Continuum of Atrial Peristalsis Initiates the Bicuspid to Quadricuspid Valve Transition.bioRxiv : the preprint server for biology · 2026Article
- Role of Cardiac CT in the Evaluation of Valvular Heart Disease.Journal of the Korean Society of Radiology · 2026Review
- Prediction of Ascending Aortic Dilation and Analysis of Influencing Factors in Bicuspid Aortic Valve Patients Using an Explainable Machine Learning Model.Cardiology research and practice · 2026Article
- In vitro characterization of hemodynamics in bicuspid aortic valves: The impact of valve and ascending aortic morphologies.Magnetic resonance in medicine · 2026Article
- Trends in Bicuspid Aortic Valve-Attributable Death in the United States From 2010 to 2020.Journal of the American Heart Association · 2025Article
- Hemodynamic characteristics of dilated ascending aorta in patients with bicuspid aortic valve.Journal of cardiothoracic surgery · 2025Article
- Bicuspid Aortic Valve Endocarditis and Q Fever.JACC. Case reports · 2025Article
- The Role of Global Longitudinal Strain in Detecting Early Left Ventricular Dysfunction in Pediatric Bicuspid Aortic Valve Patients.Children (Basel, Switzerland) · 2025Article
- Emerging imaging and circulating biomarkers in relation to underlying mechanisms in Bicuspid Aortic Valve aortopathy.International journal of cardiology. Heart & vasculature · 2025Review
- Bicuspid Aortic Valve and Sudden Cardiac Death.Life (Basel, Switzerland) · 2025Review
- Echocardiography screening of German military pilot applicants as an example for high-hazard occupations.Frontiers in public health · 2025Article
- Role of Antiplatelets and Anticoagulation Therapies in Pregnancy.Journal of clinical medicine · 2024Review
- Speckle Strain Analysis of Left Ventricular Dysfunction in Paediatric Patients with Bicuspid Aortic Valve-A Pilot Study.Children (Basel, Switzerland) · 2024Article
- Effect of aortic valve phenotype and sex on aorta dilation in patients with aortic stenosis.Open heart · 2024Observational
- Assessing the Performance of ChatGPT in Answering Patients' Questions Regarding Congenital Bicuspid Aortic Valve.Cureus · 2024Article
- A Meta-Analysis of Short-Term Outcomes of TAVR versus SAVR in Bicuspid Aortic Valve Stenosis and TAVR Results in Different Bicuspid Valve Anatomies.Journal of clinical medicine · 2023Review
- Lower incidence of new-onset severe conduction disturbances after transcatheter aortic valve implantation with bicuspid aortic valve in patients with no baseline conduction abnormality: a cross-sectional investigation in a single center in China.Frontiers in cardiovascular medicine · 2023Article
- Mild eccentric aortic regurgitation in bicuspid aortic valve causing anterior mitral leaflet perforation.Annals of pediatric cardiologyArticle
Corrections and comments
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Authors and funding
4 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The bicuspid aortic valve (BAV) is the most common congenital heart defect with an estimated prevalence of between 0.5% and 2% in the United States, representing up to 6.5 million individuals. Most individuals with BAV will develop valvular and/or aortic complications related to their BAV. How these various complications relate to one another and why they arise remain elusive. Yet, astute observations have yielded relevant classification systems that leverage valvular morphology, aortic shape, and genetic alteration patterns. Emerging evidence supports the existence of BAV phenotypes that may have different patterns of disease presentation, rates of progression, and risk of secondary complications. We review the natural history of BAV in light of known classification systems to illustrate a framework through which future hemodynamic, cell biologic, and other studies can better correlate with clinical endpoints. Consistent utilization of valvular, aortic, and genetic classification systems in the management and study of BAV may facilitate insight into the patterns of the disease, with prognostic and therapeutic significance for individuals who experience this common structural heart disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.