Evidence map›Paper›PMID 37275518›Full record

ArticleiScience2023

Large clones of pre-existing T cells drive early immunity against SARS-COV-2 and LCMV infection.

Martina Milighetti, Yanchun Peng, Cedric Tan, Michal Mark, Gayathri Nageswaran, Suzanne Byrne, Tahel Ronel, Tom Peacock, Andreas Mayer, Aneesh Chandran and 26 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Tissue determinants of the human T cell receptor repertoire.bioRxiv : the preprint server for biology · 2024
    Article
  8. Article
  9. Article
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  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

36 authors.

Martina MilighettiDivision of Infection and Immunity, University College London, London WC1E 6BT, UK.
Yanchun PengMRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
Cedric TanUCL Genetics Institute, University College London, London WC1E 6BT, UK.
Michal MarkDepartment of Systems Immunology, Weizmann Institute of Science, Rehovot 7610001, Israel.
Gayathri NageswaranDivision of Infection and Immunity, University College London, London WC1E 6BT, UK.
Suzanne ByrneDivision of Infection and Immunity, University College London, London WC1E 6BT, UK.
Tahel RonelDivision of Infection and Immunity, University College London, London WC1E 6BT, UK.
Tom PeacockDivision of Infection and Immunity, University College London, London WC1E 6BT, UK.
Andreas MayerDivision of Infection and Immunity, University College London, London WC1E 6BT, UK.
Aneesh ChandranDivision of Infection and Immunity, University College London, London WC1E 6BT, UK.
Joshua RosenheimDivision of Infection and Immunity, University College London, London WC1E 6BT, UK.
Matthew WhelanDivision of Infection and Immunity, University College London, London WC1E 6BT, UK.
Xuan YaoChinese Academy of Medical Science (CAMS) Oxford Institute (COI), University of Oxford, Oxford, UK.
Guihai LiuChinese Academy of Medical Science (CAMS) Oxford Institute (COI), University of Oxford, Oxford, UK.
Suet Ling FelceChinese Academy of Medical Science (CAMS) Oxford Institute (COI), University of Oxford, Oxford, UK.
Tao DongMRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
Alexander J MentzerWellcome Centre for Human Genetics, University of Oxford, Oxford, UK.
Julian C KnightChinese Academy of Medical Science (CAMS) Oxford Institute (COI), University of Oxford, Oxford, UK.
Francois BallouxUCL Genetics Institute, University College London, London WC1E 6BT, UK.
Erez GreensteinDepartment of Systems Immunology, Weizmann Institute of Science, Rehovot 7610001, Israel.
Shlomit Reich-ZeligerDepartment of Systems Immunology, Weizmann Institute of Science, Rehovot 7610001, Israel.
Corinna PadeBlizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London E1 4NS, UK.
Joseph M GibbonsBlizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London E1 4NS, UK.
Amanda SemperUK Health Security Agency, Porton Down, Salisbury SP4 0JG, UK.
Tim BrooksUK Health Security Agency, Porton Down, Salisbury SP4 0JG, UK.
Ashley OtterUK Health Security Agency, Porton Down, Salisbury SP4 0JG, UK.
Daniel M AltmannDepartment of Immunology and Inflammation, Imperial College London, London SW7 2BX, UK.
Rosemary J BoytonDepartment of Infectious Disease, Imperial College London, London W12 0NN, UK.
Mala K MainiDivision of Infection and Immunity, University College London, London WC1E 6BT, UK.
Aine McKnightBlizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London E1 4NS, UK.
Charlotte ManistyInstitute of Cardiovascular Sciences, University College London, London WC1E 6BT, UK.
Thomas A TreibelInstitute of Cardiovascular Sciences, University College London, London WC1E 6BT, UK.
James C MoonInstitute of Cardiovascular Sciences, University College London, London WC1E 6BT, UK.
COVIDsortium Investigators
Mahdad NoursadeghiDivision of Infection and Immunity, University College London, London WC1E 6BT, UK.
Benny ChainDivision of Infection and Immunity, University College London, London WC1E 6BT, UK.

Funding

Medical Research Council MR/N007727/1Medical Research Council MR/R02622X/1Medical Research Council MR/S019553/1Medical Research Council MR/V036939/1Medical Research Council MR/W020610/1Wellcome Trust
6 · The paper itself

Abstract

T cell responses precede antibody and may provide early control of infection. We analyzed the clonal basis of this rapid response following SARS-COV-2 infection. We applied T cell receptor (TCR) sequencing to define the trajectories of individual T cell clones immediately. In SARS-COV-2 PCR+ individuals, a wave of TCRs strongly but transiently expand, frequently peaking the same week as the first positive PCR test. These expanding TCR CDR3s were enriched for sequences functionally annotated as SARS-COV-2 specific. Epitopes recognized by the expanding TCRs were highly conserved between SARS-COV-2 strains but not with circulating human coronaviruses. Many expanding CDR3s were present at high frequency in pre-pandemic repertoires. Early response TCRs specific for lymphocytic choriomeningitis virus epitopes were also found at high frequency in the preinfection naive repertoire. High-frequency naive precursors may allow the T cell response to respond rapidly during the crucial early phases of acute viral infection.

Indexed as

Biological sciencesCell biologyImmunityImmunology

Identifiers

PMID37275518
PMCPMC10201888

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.