Evidence map›Paper›PMID 37275517›Full record

ArticleiScience2023

Natural heteroclitic-like peptides are generated by SARS-CoV-2 mutations.

Camilla Tiezzi, Andrea Vecchi, Marzia Rossi, Davide Cavazzini, Angelo Bolchi, Diletta Laccabue, Sara Doselli, Amalia Penna, Luca Sacchelli, Federica Brillo and 20 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors at 4 institutions in 3 countries.

Camilla TiezziDepartment of Medicine and Surgery, University of Parma, Parma, Italy.
Andrea VecchiLaboratory of Viral Immunopathology, Unit of Infectious Diseases and Hepatology, Azienda Ospedaliero-Universitaria di Parma, Parma, Italy.
Marzia RossiDepartment of Medicine and Surgery, University of Parma, Parma, Italy.
Davide CavazziniDepartment of Chemistry, Life Sciences and Environmental Sustainability, University of Parma, Parma, Italy.
Angelo BolchiDepartment of Chemistry, Life Sciences and Environmental Sustainability, University of Parma, Parma, Italy.
Diletta LaccabueDepartment of Medicine and Surgery, University of Parma, Parma, Italy.
Sara DoselliLaboratory of Viral Immunopathology, Unit of Infectious Diseases and Hepatology, Azienda Ospedaliero-Universitaria di Parma, Parma, Italy.
Amalia PennaLaboratory of Viral Immunopathology, Unit of Infectious Diseases and Hepatology, Azienda Ospedaliero-Universitaria di Parma, Parma, Italy.
Luca SacchelliLaboratory of Viral Immunopathology, Unit of Infectious Diseases and Hepatology, Azienda Ospedaliero-Universitaria di Parma, Parma, Italy.
Federica BrilloLaboratory of Viral Immunopathology, Unit of Infectious Diseases and Hepatology, Azienda Ospedaliero-Universitaria di Parma, Parma, Italy.
Tiziana MeschiDepartment of Medicine and Surgery, University of Parma, Parma, Italy.
Andrea TicinesiDepartment of Medicine and Surgery, University of Parma, Parma, Italy.
Antonio NouvenneGeriatric-Rehabilitation Department, Azienda Ospedaliero-Universitaria di Parma, Parma, Italy.
Gaetano DonofrioDepartment of Veterinary Science, University of Parma, Parma, Italy.
Paola ZanelliUnità di Immunogenetica dei Trapianti, Azienda Ospedaliero Universitaria di Parma, Parma, Italy.
Magda BenecchiUnità di Immunogenetica dei Trapianti, Azienda Ospedaliero Universitaria di Parma, Parma, Italy.
Silvia GiuliodoriUnità di Immunogenetica dei Trapianti, Azienda Ospedaliero Universitaria di Parma, Parma, Italy.
Paola FisicaroLaboratory of Viral Immunopathology, Unit of Infectious Diseases and Hepatology, Azienda Ospedaliero-Universitaria di Parma, Parma, Italy.
Ilaria MontaliDepartment of Medicine and Surgery, University of Parma, Parma, Italy.
Camilla Ceccatelli BertiDepartment of Medicine and Surgery, University of Parma, Parma, Italy.
Valentina ReverberiLaboratory of Viral Immunopathology, Unit of Infectious Diseases and Hepatology, Azienda Ospedaliero-Universitaria di Parma, Parma, Italy.
Anna MontaliDepartment of Medicine and Surgery, University of Parma, Parma, Italy.
Simona UrbaniUO Immunoematologia e Medicina Trasfusionale, Dipartimento Diagnostico, Azienda Ospedaliero-Universitaria di Parma, Parma, Italy.
Giuseppe PedrazziDepartment of Neuroscience - Biophysics and Medical Physics Unit, University of Parma, Parma, Italy.
Gabriele MissaleLaboratory of Viral Immunopathology, Unit of Infectious Diseases and Hepatology, Azienda Ospedaliero-Universitaria di Parma, Parma, Italy.
Amalio TelentiVir Biotechnology, San Francisco, CA 94158, USA.
Davide CortiHumabs Biomed SA, a subsidiary of Vir Biotechnology, Bellinzona, Switzerland.
Simone OttonelloDepartment of Chemistry, Life Sciences and Environmental Sustainability, University of Parma, Parma, Italy.
Carlo FerrariLaboratory of Viral Immunopathology, Unit of Infectious Diseases and Hepatology, Azienda Ospedaliero-Universitaria di Parma, Parma, Italy.
Carolina BoniLaboratory of Viral Immunopathology, Unit of Infectious Diseases and Hepatology, Azienda Ospedaliero-Universitaria di Parma, Parma, Italy.
Ospedale di Parma · ITUniversity of Parma · ITVir Biotechnology (Switzerland) · CHVIR Biotechnology (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Humoral immunity is sensitive to evasion by SARS-CoV-2 mutants, but CD8 T cells seem to be more resistant to mutational inactivation. By a systematic analysis of 30 spike variant peptides containing the most relevant VOC and VOI mutations that have accumulated overtime, we show that in vaccinated and convalescent subjects, mutated epitopes can have not only a neutral or inhibitory effect on CD8 T cell recognition but can also enhance or generate

Indexed as

ImmunologySequence analysisSequence homologyVirology

Identifiers

PMID37275517
PMCPMC10200277
OpenAlexW4377194455

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.