SynthesisFrontiers in public health2023
Toxicological effects of micro/nano-plastics on mouse/rat models: a systematic review and meta-analysis.
Synthesis in Frontiers in public health, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- The impact of microplastics on the mice gut microbiome: a meta-analysis.Scientific reports · 2026Pooled it
- Dose-Dependent Toxicological Effects of Polyvinyl Chloride and Polystyrene Microplastics on Wistar Albino Rats.Journal of applied toxicology : JAT · 2026Article
- Gaps between Laboratory Experiments and Real-World Exposure: Toxicological Assessment of Microplastics Is Based on Inadequate Evidence.Environment & health (Washington, D.C.) · 2026Review
- Microplastics and Nanoplastics in the Human Intestine: A Review of Health Implications and Possible Dietary Interventions.Advances in nutrition (Bethesda, Md.) · 2026Review
- Bioplastics Toxicity upon Ingestion: A Critical Review of Biotransformation and Gastrointestinal Effects.Polymers · 2026Review
- Postnatal development outcomes in mice after gestational exposure to polystyrene nanoplastics.Scientific reports · 2026Article
- Polyethylene terephthalate microplastics impair erectile function through macrophage mediated cGAS-STING ferroptosis.iScience · 2026Article
- Microplastics' Impact on the Development of AOM/DSS-Induced Colitis-Associated Colorectal Cancer in Mice.International journal of molecular sciences · 2025Article
- Endocrine Disrupting Agents: Toxicological Aspects on Male Reproduction.Reproductive sciences (Thousand Oaks, Calif.) · 2025Review
- Post-mortem evidence of microplastic bioaccumulation in human organs: insights from advanced imaging and spectroscopic analysis.Archives of toxicology · 2025Article
- Nano- and Microplastics in the Brain: An Emerging Threat to Neural Health.Nanomaterials (Basel, Switzerland) · 2025Review
- Health impacts of microplastic and nanoplastic exposure.Nature medicine · 2025Review
- Synergistic Effects of Polystyrene Nanoplastics and Cadmium on the Metabolic Processes and Their Accumulation in Hydroponically Grown Lettuce (Journal of agricultural and food chemistry · 2025Article
- Adipose tissue as target of environmental toxicants: focus on mitochondrial dysfunction and oxidative inflammation in metabolic dysfunction-associated steatotic liver disease.Molecular and cellular biochemistry · 2025Review
- Nanoplastics as Gene and Epigenetic Modulators of Endocrine Functions: A Perspective.International journal of molecular sciences · 2025Review
- Strategies for the Remediation of Micro- and Nanoplastics from Contaminated Food and Water: Advancements and Challenges.Journal of xenobiotics · 2025Review
- Intestinal Barrier Damage and Growth Retardation Caused by Exposure to Polystyrene Nanoplastics Through Lactation Milk in Developing Mice.Nanomaterials (Basel, Switzerland) · 2025Article
- Development of Eco-Friendly Packaging Films from Soyhull Lignocellulose: Towards Valorizing Agro-Industrial Byproducts.Foods (Basel, Switzerland) · 2024Article
- Invisible but Insidious Effects of Microplastics.Molecules (Basel, Switzerland) · 2024Article
- Concerning influences of micro/nano plastics on female reproductive health: focusing on cellular and molecular pathways from animal models to human studies.Reproductive biology and endocrinology : RB&E · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Micro/nano-plastics (MNPs) are considered a heterogeneous class of environmental contaminants that cause multiple toxic effects on biological species. As the commonly used mammalian models to study the effects of MNPs with regard to their toxic effects, the mouse and rat models are making a great contribution to the disciplines of environmental toxicology and medical health. However, the toxic effects of MNPs have not been systematically summarized. Therefore, a systematic review and a meta-analysis of the toxic effects of MNPs on mouse/rat models were conducted. A total of seven main categories were established in this systematic review, and 24 subcategories were further divided according to the specific physiological significance of the endpoint or the classification of the physiological system, which covered all the selected pieces of literature. A total of 1,762 biological endpoints were found, and 52.78% of them were significantly affected. This fact indicates that there are relative factors, including the size, polymer type, concentration, and exposure time of MNPs and different sexes of mouse/rat models that could significantly affect the biological endpoints. These biological endpoints can be classified into various factors, such as the dose-response relationships between MNP concentration and physiological categories of the nervous system, growth, reproduction, digestive tract histopathology, and inflammatory cytokine level, among others. MNPs negatively affected the blood glucose metabolism, lipid metabolism, and reproductive function in mice. The reproductive function in male mice is more sensitive to the toxic effects of MNPs. These findings also provide insights into and directions for exploring the evidence and mechanisms of the toxic effects of MNPs on human health. It is clear that more research is required on the pathological mechanisms at the molecular level and the long-term effects of tissue accumulation.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.