Evidence map›Paper›PMID 37275218›Full record

ArticleOptica2023

Interferometric diffusing wave spectroscopy imaging with an electronically variable time-of-flight filter.

Mingjun Zhao, Wenjun Zhou, Santosh Aparanji, Dibbyan Mazumder, Vivek J Srinivasan

Open access · goldAbstract read
In one paragraph

Article in Optica, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 30 citations in OpenAlex.

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  20. Comprehensive Optimization of Interferometric Diffusing Wave Spectroscopy (iDWS).IEEE journal of selected topics in quantum electronics : a publication of the IEEE Lasers and Electro-optics Society
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Mingjun ZhaoDepartment of Radiology, New York University Langone Health, 660 First Avenue, New York, New York 10016, USA.ORCID 0000-0002-8657-4413
Wenjun ZhouDepartment of Biomedical Engineering, University of California Davis, 1 Shields Ave, Davis, California 95616, USA.ORCID 0000-0002-6000-253X
Santosh AparanjiDepartment of Radiology, New York University Langone Health, 660 First Avenue, New York, New York 10016, USA.
Dibbyan MazumderDepartment of Radiology, New York University Langone Health, 660 First Avenue, New York, New York 10016, USA.
Vivek J SrinivasanDepartment of Radiology, New York University Langone Health, 660 First Avenue, New York, New York 10016, USA.ORCID 0000-0001-9683-1949
NYU Langone Health · USChina Jiliang University · CN

Funding

TRD3: Data Analytics and Intelligent Systems (AI-ML-DL-Visualization)P41EB032840 · NIBIB · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Griffith R. Harsh · 2022 to 2026
$6.7M
True Sub-Micron Ocular Diagnostics with Visible Light Optical Coherence TomographyR01EY031469 · NEI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI SRINIVASAN, VIVEK JAY · 2020 to 2023
$2.3M
Human Brain Interferometers for Better Blood Flow MonitoringR01EB029747 · NIBIB · UNIVERSITY OF CALIFORNIA AT DAVIS · PI SRINIVASAN, VIVEK JAY · 2020 to 2023
$2.2M
Imaging Neuronal and Capillary Dysfunction Deep in the Rodent Brain in vivo Using 1700 NM Optical Coherence Microscopy and Tracer-Based KineticsR01NS094681 · NINDS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI SRINIVASAN, VIVEK JAY · 2015 to 2019
$1.6M
NEI NIH HHS R01 EY031469NIBIB NIH HHS P41 EB032840NIBIB NIH HHS R01 EB029747NINDS NIH HHS R01 NS094681
6 · The paper itself

Abstract

Diffuse optics (DO) is a light-based technique used to study the human brain, but it suffers from low brain specificity. Interferometric diffuse optics (iDO) promises to improve the quantitative accuracy and depth specificity of DO, and particularly, coherent light fluctuations (CLFs) arising from blood flow. iDO techniques have alternatively achieved either time-of-flight (TOF) discrimination or highly parallel detection, but not both at once. Here, we break this barrier with a single iDO instrument. Specifically, we show that rapid tuning of a temporally coherent laser during the sensor integration time increases the effective linewidth seen by a highly parallel interferometer. Using this concept to create a continuously variable and user-specified TOF filter, we demonstrate a solution to the canonical problem of DO, measuring optical properties. Then, with a deep TOF filter, we reduce scalp sensitivity of CLFs by 2.7 times at 1 cm source-collector separation. With this unique combination of desirable features, i.e., TOF-discrimination, spatial localization, and highly parallel CLF detection, we perform multiparametric imaging of light intensities and CLFs via the human forehead.

Identifiers

PMID37275218
PMCPMC10238083
OpenAlexW4308991544

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.