Evidence map›Paper›PMID 37274924›Full record

ArticleAsian journal of pharmaceutical sciences2023

Implantation of hydrogel-liposome nanoplatform inhibits glioblastoma relapse by inducing ferroptosis.

Zixiao Wang, Zihao Liu, Shan Wang, Xin Bing, Xiaoshuai Ji, Dong He, Min Han, Yanbang Wei, Chanyue Wang, Qian Xia and 8 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Asian journal of pharmaceutical sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 3 pooled it
8.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 3 syntheses or guidelines pooled it, 33 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Review
  5. Review
  6. Review
  7. Review
  8. Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Review
  16. Review
  17. Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 5 institutions in 1 country.

Zixiao WangDepartment of Histology and Embryology, School of Basic Medical Sciences, Shandong University, Jinan 250012, China.
Zihao LiuDepartment of Neurosurgery, Shandong Provincial Hospital, Shandong University, Jinan 250021, China.
Shan WangShandong Key Laboratory of Reproductive Medicine, Department of Obstetrics and Gynecology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, China.
Xin BingDepartment of Otolaryngology Head and neck surgery, Shandong Provincial Hospital, Shandong University, Jinan 250021, China.
Xiaoshuai JiDepartment of Neurosurgery, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan 250014, China.
Dong HeDepartment of Neurosurgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250102, China.
Min HanDepartment of Neurosurgery, Shandong Provincial Qianfoshan Hospital Affiliated to Shandong First Medical University, Jinan 250014, China.
Yanbang WeiDepartment of Histology and Embryology, School of Basic Medical Sciences, Shandong University, Jinan 250012, China.
Chanyue WangDepartment of Histology and Embryology, School of Basic Medical Sciences, Shandong University, Jinan 250012, China.
Qian XiaDepartment of Endocrinology, Qilu Hospital, Shandong University, Jinan 250012, China.
Jianqiao YangDepartment of Gastroenterological Surgery, Peking University People's Hospital, Beijing 100032, China.
Jiajia GaoDepartment of Neurosurgery, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan 250014, China.
Xianyong YinDepartment of Neurosurgery, Shandong Provincial Qianfoshan Hospital Affiliated to Shandong First Medical University, Jinan 250014, China.
Zhihai WangDepartment of Neurosurgery, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan 250014, China.
Zehan ShangDepartment of Neurosurgery, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan 250014, China.
Jiacan XuDepartment of Histology and Embryology, School of Basic Medical Sciences, Shandong University, Jinan 250012, China.
Tao XinDepartment of Neurosurgery, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan 250014, China.
Qian LiuDepartment of Histology and Embryology, School of Basic Medical Sciences, Shandong University, Jinan 250012, China.
Shandong University · CNShandong Provincial Hospital · CNShandong Provincial QianFoShan Hospital · CNPeking University · CNQilu Hospital of Shandong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glioblastoma is acknowledged as the most aggressive cerebral tumor in adults. However, the efficacy of current standard therapy is seriously undermined by drug resistance and suppressive immune microenvironment. Ferroptosis is a recently discovered form of iron-dependent cell death that may have excellent prospect as chemosensitizer. The utilization of ferropotosis inducer Erastin could significantly mediate chemotherapy sensitization of Temozolomide and exert anti-tumor effects in glioblastoma. In this study, a combination of hydrogel-liposome nanoplatform encapsulated with Temozolomide and ferroptosis inducer Erastin was constructed. The αvβ3 integrin-binding peptide cyclic RGD was utilized to modify codelivery system to achieve glioblastoma targeting strategy. As biocompatible drug reservoirs, cross-linked GelMA (gelatin methacrylamide) hydrogel and cRGD-coated liposome realized the sustained release of internal contents. In the modified intracranial tumor resection model, GelMA-liposome system achieved slow release of Temozolomide and Erastin

Indexed as

Drug resistanceFerroptosisGlioblastomaHydrogel-liposomeImmunomodulationRelapse

Identifiers

PMID37274924
PMCPMC10232663
OpenAlexW4361208312

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.