ArticleArchives of Razi Institute2022
Overexpressed Toll-Like Receptor 2 and the Influence on the Severity of Acute Ischemic Stroke.
Article in Archives of Razi Institute, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 4 citations in OpenAlex.
- Identification and Experimental Validation of Biomarkers Associated with PI3K/AKT Signaling Pathway in Spinal Cord Injury.Molecular neurobiology · 2026Article
- Identification and validation of microglia-associated genes in ischemic stroke using single-cell and bulk RNA-seq.Molecular brain · 2025Article
- Neuroprotective Effects of AER-271 in a tMCAO Mouse Model: Modulation of Autophagy, Apoptosis, and Inflammation.Inflammation · 2025Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Brain insult caused by cerebral ischemia/reperfusion is a complex pathophysiological process in which inflammatory reaction is thought to play a crucial part. Toll-like receptors are a sort of transmembrane proteins that can initiate inflammatory reactions upon identifying either endogenous stress or changes in the innate immune system's molecular patterns that are damage-associated or even exogenous pathogen-associated molecular patterns. TLR2, amongst all other Toll-like receptors, is recognized to have a more vital role in the pathologic progress of brain insult attributed to ischemia/reperfusion. The current study aimed to address the impact of TLR2 overexpression on the severity of acute ischemic stroke. A case-control study was piloted on two groups of participants; the first group (cases) was 95 patients suffering from acute ischemic stroke, while the second one (controls) was 50 volunteers free of disease. Matching controls to patients was done according to age (within five years) and gender. The study extended from the beginning of February to the end of August 2020. Participants in both groups were collected from Merjan Medical city in Babylon Governorate. Values of Toll-like receptor 5 were calculated with the real-time polymerase chain reaction (RT-PCR) technique. Statistically, a significant difference was found between the patients and controls concerning the values of TLR2 (
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