ReviewNeurobiology of pain (Cambridge, Mass.)
Elucidation of the mechanisms of exercise-induced hypoalgesia and pain prolongation due to physical stress and the restriction of movement.
Review in Neurobiology of pain (Cambridge, Mass.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 13 citations in OpenAlex.
- The Impact of a Single Session of Sprint Interval Training (SIT) on Pain Pressure Threshold (PPT) in Healthy Adults.Sports (Basel, Switzerland) · 2026Article
- Children with suspected anterior cutaneous nerve entrapment syndrome (ACNES), it's not all the abdominal wall.BMJ paediatrics open · 2026Article
- Pressure point: blood flow restriction exercise and the pain paradox in musculoskeletal injury and persistent pain populations-a narrative review.Frontiers in pain research (Lausanne, Switzerland) · 2026Review
- Looking Inwards: The Role of Self-Care, Self-Management and Self-Healing in Musculoskeletal Pain.Musculoskeletal care · 2025Article
- Chronic low back pain and exercise: a molecular perspective on aerobic and anaerobic core training.Molecular biology reports · 2025Review
- The Effect of Eight Weeks of Passive Heat Therapy on Mental Health, Sleep, and Chronic Pain in Persons with Spinal Cord Injury: A Pilot Study.Journal of clinical medicine · 2025Article
- The impact of thermal and auditory unpleasant stimulus on explicit motor imagery in healthy individuals: An experimental study.PloS one · 2025Article
- Communicating pain: emerging axonal signaling in peripheral neuropathic pain.Frontiers in neuroanatomy · 2024Review
- Is exercise therapy the first-line treatment for chronic pain?Neurobiology of pain (Cambridge, Mass.)Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Persistent pain signals cause brain dysfunction and can further prolong pain. In addition, the physical restriction of movement (e.g., by a cast) can cause stress and prolong pain. Recently, it has been recognized that exercise therapy including rehabilitation is effective for alleviating chronic pain. On the other hand, physical stress and the restriction of movement can prolong pain. In this review, we discuss the neural circuits involved in the control of pain prolongation and the mechanisms of exercise-induced hypoalgesia (EIH). We also discuss the importance of the mesolimbic dopaminergic network in these phenomena.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.