Evidence map›Paper›PMID 37274832›Full record

ArticleBrain communications2023

Detection of grey matter microstructural substrates of neurodegeneration in multiple sclerosis.

Eva A Krijnen, Andrew W Russo, Elsa Salim Karam, Hansol Lee, Florence L Chiang, Menno M Schoonheim, Susie Y Huang, Eric C Klawiter

Open access · goldAbstract read
In one paragraph

Article in Brain communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
5.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 22 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Eva A KrijnenDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.ORCID https://orcid.org/0000-0002-3628-4127
Andrew W RussoDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Elsa Salim KaramDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Hansol LeeDepartment of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA.
Florence L ChiangDepartment of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA.
Menno M SchoonheimMS Center Amsterdam, Anatomy and Neurosciences, Amsterdam Neuroscience, Amsterdam UMC location VUmc, 1081 HV Amsterdam, The Netherlands.ORCID https://orcid.org/0000-0002-2504-6959
Susie Y HuangDepartment of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA.
Eric C KlawiterDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Harvard University · USAmsterdam Neuroscience · NL

Funding

CONNECTOME 2.0: DEVELOPING THE NEXT GENERATION HUMAN MRI SCANNER FOR BRIDGING STUDIES OF THE MICRO-, MESO- AND MACRO-CONNECTOMEU01EB026996 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI BASSER, PETER J., HUANG, SUSIE YI · 2018 to 2022
$14.2M
Toward a Validated in Vivo Imaging Marker of Axonal Damage Predictive of Progressive Disability in Multiple SclerosisR01NS118187 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI HUANG, SUSIE YI · 2021 to 2025
$2.8M
Next-generation 3 Tesla Human MRI SystemS10OD032184 · OD · MASSACHUSETTS GENERAL HOSPITAL · PI HUANG, SUSIE YI · 2023 to 2023
$2.0M
Characterizing axonal damage in multiple sclerosis using TractCaliber MRIK23NS096056 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI HUANG, SUSIE YI · 2016 to 2020
$877k
NIBIB NIH HHS U01 EB026996NIH HHS S10 OD032184NINDS NIH HHS K23 NS096056NINDS NIH HHS R01 NS118187
6 · The paper itself

Abstract

Multiple sclerosis features complex pathological changes in grey matter that begin early and eventually lead to diffuse atrophy. Novel approaches to image grey-matter microstructural alterations

Indexed as

advanced diffusion imaginggrey mattermultiple sclerosisneurodegeneration

Identifiers

PMID37274832
PMCPMC10233898
OpenAlexW4377965862

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.