Body mass index and clinical outcomes in patients with heart failure with preserved ejection fraction mediated by diastolic blood pressure status?

YingQiu Hu, ZhenBang Gu, MeiLing Xu, WenFeng He, LiDong Wu, ZhiCheng Xu, LinJuan Guo

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Article in Heliyon, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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7 authors.

YingQiu HuEmergency Department of the Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.

ZhenBang GuMedical School of Nanchang University, Nanchang, Jiangxi, China.

MeiLing XuUrology Department of the Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.

WenFeng HeDepartment of Medical Genetics, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.

LiDong WuEmergency Department of the Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.

ZhiCheng XuDepartment of Cardiology, Jiangxi Provincial People's Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, Jiangxi, China.

LinJuan GuoDepartment of Cardiology, Jiangxi Provincial People's Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, Jiangxi, China.

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6 · The paper itself

Abstract

Background: The "obesity paradox" has been elucidated in patients with heart failure (HF). Current guidelines introduce a target diastolic blood pressure (DBP) < 80 mmHg but >70 mmHg in HF patients. Due to reduced coronary perfusion, low DBP has a deleterious impact on cardiovascular outcomes. This present study aimed to assess the relationship between BMI and adjudicated clinical outcomes in HFpEF patients according to the status of DBP. Methods: We analyzed the data in 1749 HFpEF patients from the Americas of the TOPCAT (Treatment of Preserved Cardiac Function Heart Failure with an Aldosterone Antagonist) Trial. The population was stratified by DBP (<70 mmHg, and ≥70 mmHg) and BMI strata (normal weight, overweight, and obesity). Cox proportional hazards models and competing-risks regression analysis were performed. Results: At baseline, the median BMI and DBP were 32.9 kg/m Conclusions: The obesity paradox was observed in patients with HFpEF, regardless of DBP strata (<70 mmHg, and ≥70 mmHg).

Indexed as

Body mass indexDiastolic blood pressureHeart failureObesityObesity paradox

Identifiers

PMID37274719

DOI10.1016/j.heliyon.2023.e16515

PMCPMC10238725

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