Evidence map›Paper›PMID 37274647›Full record

ArticleHeliyon2023

Homocysteine levels, H-Hypertension, and the MTHFR C677T genotypes: A complex interaction.

Cynthia Al Hageh, Eman Alefishat, Michella Ghassibe-Sabbagh, Daniel E Platt, Hamdan Hamdan, Raya Tcheroyan, Elie Chammas, Siobhán O'Sullivan, Antoine Abchee, Binyan Wang and 3 more

Abstract read
In one paragraph

Article in Heliyon, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Observational
  2. Article
  3. Observational
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Cynthia Al HagehCollege of Medicine and Health Sciences, Khalifa University of Science and Technology, Abu Dhabi, United Arab Emirates.
Eman AlefishatCollege of Medicine and Health Sciences, Khalifa University of Science and Technology, Abu Dhabi, United Arab Emirates.
Michella Ghassibe-SabbaghSchool of Arts and Sciences, Lebanese American University, Beirut, Lebanon.
Daniel E PlattComputational Biology Center, IBM TJ Watson Research Centre, Yorktown Hgts, NY, USA.
Hamdan HamdanCollege of Medicine and Health Sciences, Khalifa University of Science and Technology, Abu Dhabi, United Arab Emirates.
Raya TcheroyanSchool of Medicine, American University of Beirut, Beirut, Lebanon.
Elie ChammasSchool of Medicine, Lebanese University, Beirut, Lebanon.
Siobhán O'SullivanCollege of Medicine and Health Sciences, Khalifa University of Science and Technology, Abu Dhabi, United Arab Emirates.
Antoine AbcheeSheikh Shakhbout Medical City, Abu Dhabi, United Arab Emirates.
Binyan WangShenzhen Evergreen Medical Institute, Shenzhen, China.
Xiping XuKey Laboratory of Precision Nutrition and Food Quality, Ministry of Education, Department of Nutrition and Health, College of Food Sciences and Nutritional Engineering, China Agricultural University, Beijing, China.
Moni NaderCollege of Medicine and Health Sciences, Khalifa University of Science and Technology, Abu Dhabi, United Arab Emirates.
Pierre ZallouaCollege of Medicine and Health Sciences, Khalifa University of Science and Technology, Abu Dhabi, United Arab Emirates.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and objectives: High homocysteine levels are associated with increased risk of hypertension and stroke. Homocysteine is metabolized by the methylenetetrahydrofolate reductase ( Methods and results: Genotype frequency of Conclusions: We found an association of homocysteine with hypertension, hypertensive medication, and stroke risk among patients with the

Indexed as

C677TDiureticsHHcyH-hypertensionMTHFRrs1801133

Identifiers

PMID37274647
PMCPMC10238895

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.